HSV-2 Specifically Down Regulates HLA-C Expression to Render HSV-2-Infected DCs Susceptible to NK Cell Killing

Moran Elboim; Inna Grodzovski; Esther Djian; Dana G. Wolf; Ofer Mandelboim

doi:10.1371/journal.ppat.1003226

Loading metrics

Open Access

Peer-reviewed

Research Article

HSV-2 Specifically Down Regulates HLA-C Expression to Render HSV-2-Infected DCs Susceptible to NK Cell Killing

Moran Elboim,

Affiliation The Lautenberg Center for General and Tumor Immunology, The BioMedical Research Institute Israel-Canada of the Faculty of Medicine, The Hebrew University Hadassah Medical School, Jerusalem, Israel
⨯
Inna Grodzovski,

Affiliation The Lautenberg Center for General and Tumor Immunology, The BioMedical Research Institute Israel-Canada of the Faculty of Medicine, The Hebrew University Hadassah Medical School, Jerusalem, Israel
⨯
Esther Djian,

Affiliation Virology Unit, Hadassah Hospital, The Hebrew University Hadassah Medical School, Jerusalem, Israel
⨯
Dana G. Wolf,

Affiliation Virology Unit, Hadassah Hospital, The Hebrew University Hadassah Medical School, Jerusalem, Israel
⨯
Ofer Mandelboim

* E-mail: oferm@ekmd.huji.ac.il

Affiliation The Lautenberg Center for General and Tumor Immunology, The BioMedical Research Institute Israel-Canada of the Faculty of Medicine, The Hebrew University Hadassah Medical School, Jerusalem, Israel
⨯

HSV-2 Specifically Down Regulates HLA-C Expression to Render HSV-2-Infected DCs Susceptible to NK Cell Killing

Moran Elboim,
Inna Grodzovski,
Esther Djian,
Dana G. Wolf,
Ofer Mandelboim

Published: March 28, 2013
https://doi.org/10.1371/journal.ppat.1003226

About the Authors

Moran Elboim

Affiliation The Lautenberg Center for General and Tumor Immunology, The BioMedical Research Institute Israel-Canada of the Faculty of Medicine, The Hebrew University Hadassah Medical School, Jerusalem, Israel

Inna Grodzovski

Esther Djian

Affiliation Virology Unit, Hadassah Hospital, The Hebrew University Hadassah Medical School, Jerusalem, Israel

Dana G. Wolf

Affiliation Virology Unit, Hadassah Hospital, The Hebrew University Hadassah Medical School, Jerusalem, Israel

Ofer Mandelboim

* E-mail: oferm@ekmd.huji.ac.il

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ME IG OM. Performed the experiments: ME IG. Analyzed the data: ME OM. Contributed reagents/materials/analysis tools: ME IG ED DGW. Wrote the paper: ME OM.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

NK cells
Is the Subject Area "NK cells" applicable to this article?

Thanks for your feedback.
Herpes simplex virus-2
Is the Subject Area "Herpes simplex virus-2" applicable to this article?

Thanks for your feedback.
MicroRNAs
Is the Subject Area "MicroRNAs" applicable to this article?

Thanks for your feedback.
Cell staining
Is the Subject Area "Cell staining" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.
Antigen-presenting cells
Is the Subject Area "Antigen-presenting cells" applicable to this article?

Thanks for your feedback.
Antigen presentation
Is the Subject Area "Antigen presentation" applicable to this article?

Thanks for your feedback.
Major histocompatibility complex
Is the Subject Area "Major histocompatibility complex" applicable to this article?

Thanks for your feedback.