About the Authors

John E. Tavis

tavisje@slu.edu

Affiliations Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America, Saint Louis University Liver Center, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America

Xiaohong Cheng

Contributed equally to this work with: Xiaohong Cheng, Yuan Hu

Affiliation Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America

Yuan Hu

Contributed equally to this work with: Xiaohong Cheng, Yuan Hu

Affiliations Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America, Key Laboratory of Molecular Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, People's Republic of China

Michael Totten

Affiliation Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America

Feng Cao

Affiliations Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America, Saint Louis University Liver Center, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America

Eleftherios Michailidis

Affiliation Department of Infectious Diseases and Microbiology, University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania, United States of America

Rajeev Aurora

Affiliation Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America

Marvin J. Meyers

Affiliation Center for World Health and Medicine, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America

E. Jon Jacobsen

Affiliation Center for World Health and Medicine, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America

Michael A. Parniak

Affiliation Department of Infectious Diseases and Microbiology, University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania, United States of America

Stefan G. Sarafianos

Affiliation Department of Molecular Microbiology and Immunology and Department of Biochemistry, University of Missouri School of Medicine, Christopher S. Bond Life Sciences Center, Columbia, Missouri, United States of America

Competing Interests

I have read the journal's policy and have the following conflicts: JET will be an inventor on a pending patent application covering this RNAseH assay and the compounds identified with it. SGS and MAP will be inventors on patent application(s) covering compounds #12-15. This does not alter our adherence to all PLoS Pathogens policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JET YH FC EM RA MJM EJJ MAP SGS. Performed the experiments: JET XC YH MT FC EM. Analyzed the data: JET XC YH FC EM SGS. Contributed reagents/materials/analysis tools: JET RA MJM EJJ MAP SGS. Wrote the paper: JET YH SGS.