About the Authors
- Jamie J. Arnold
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* E-mail: jja5@psu.edu (JJA); cec9@psu.edu (CEC)
Affiliation Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America
- Suresh D. Sharma
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Affiliation Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America
- Joy Y. Feng
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Affiliation Gilead Sciences, Inc., Foster City, California, United States of America
- Adrian S. Ray
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Affiliation Gilead Sciences, Inc., Foster City, California, United States of America
- Eric D. Smidansky
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Affiliation Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America
- Maria L. Kireeva
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Affiliation Frederick National Laboratory for Cancer Research, NCI, Frederick, Maryland, United States of America
- Aesop Cho
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Affiliation Gilead Sciences, Inc., Foster City, California, United States of America
- Jason Perry
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Affiliation Gilead Sciences, Inc., Foster City, California, United States of America
- Jennifer E. Vela
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Affiliation Gilead Sciences, Inc., Foster City, California, United States of America
- Yeojin Park
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Affiliation Gilead Sciences, Inc., Foster City, California, United States of America
- Yili Xu
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Affiliation Gilead Sciences, Inc., Foster City, California, United States of America
- Yang Tian
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Affiliation Gilead Sciences, Inc., Foster City, California, United States of America
- Darius Babusis
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Affiliation Gilead Sciences, Inc., Foster City, California, United States of America
- Ona Barauskus
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Affiliation Gilead Sciences, Inc., Foster City, California, United States of America
- Blake R. Peterson
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Affiliation Department of Medicinal Chemistry, The University of Kansas, Lawrence, Kansas, United States of America
- Averell Gnatt
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Affiliation Department of Pharmacology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
- Mikhail Kashlev
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Affiliation Frederick National Laboratory for Cancer Research, NCI, Frederick, Maryland, United States of America
- Weidong Zhong
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Current address: Novartis Institutes for BioMedical Research, Emeryville, California, United States of America.
Affiliation Gilead Sciences, Inc., Foster City, California, United States of America
- Craig E. Cameron
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* E-mail: jja5@psu.edu (JJA); cec9@psu.edu (CEC)
Affiliation Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America
Competing Interests
JYF, ASR, AC, JP, JEV, YP, YX, YT, DB, OB and WZ are current or former employees and shareholders of Gilead Sciences, Inc. that is responsible for the active clinical development of GS-7977 and has a partnership with Roche related to the development of mericitabine. JJA and CEC are collaborating with INDIGO Biosciences, Inc. for the development and distribution of mitochondrial toxicity assays. This does not alter our adherence to all PLOS Pathogens policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: JJA SDS JYF ASR EDS MLK MK WZ CEC. Performed the experiments: JJA SDS JYF ASR EDS MLK AC JP JEV YP YX YT DB OB. Analyzed the data: JJA SDS JYF ASR EDS MLK MK CEC. Contributed reagents/materials/analysis tools: JYF ASR BRP AG MK WZ CEC. Wrote the paper: JJA JYF ASR EDS MLK CEC.