About the Authors

Steven Johnson

Contributed equally to this work with: Steven Johnson, Lionel Tan, Stijn van der Veen, Joseph Caesar, Elena Goicoechea De Jorge, Rachel J. Harding

Affiliation Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom

Lionel Tan

Contributed equally to this work with: Steven Johnson, Lionel Tan, Stijn van der Veen, Joseph Caesar, Elena Goicoechea De Jorge, Rachel J. Harding

Affiliation Centre for Molecular Microbiology and Infection, Imperial College, London, United Kingdom

Stijn van der Veen

Contributed equally to this work with: Steven Johnson, Lionel Tan, Stijn van der Veen, Joseph Caesar, Elena Goicoechea De Jorge, Rachel J. Harding

Affiliation Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom

Joseph Caesar

Contributed equally to this work with: Steven Johnson, Lionel Tan, Stijn van der Veen, Joseph Caesar, Elena Goicoechea De Jorge, Rachel J. Harding

Affiliation Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom

Elena Goicoechea De Jorge

Contributed equally to this work with: Steven Johnson, Lionel Tan, Stijn van der Veen, Joseph Caesar, Elena Goicoechea De Jorge, Rachel J. Harding

Affiliation Centre for Complement and Inflammation Research (CCIR), Department of Medicine, Imperial College, London, United Kingdom

Rachel J. Harding

Contributed equally to this work with: Steven Johnson, Lionel Tan, Stijn van der Veen, Joseph Caesar, Elena Goicoechea De Jorge, Rachel J. Harding

Affiliation Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom

Xilian Bai

Affiliation Vaccine Evaluation Unit, Public Health Laboratory, Manchester Medical Microbiology Partnership, Manchester, United Kingdom

Rachel M. Exley

Affiliation Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom

Philip N. Ward

Affiliation Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom

Nicola Ruivo

Affiliation Centre for Molecular Microbiology and Infection, Imperial College, London, United Kingdom

Kaushali Trivedi

Affiliation Centre for Molecular Microbiology and Infection, Imperial College, London, United Kingdom

Elspeth Cumber

Affiliation Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom

Rhian Jones

Affiliation Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom

Luke Newham

Affiliation Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom

David Staunton

Affiliation Department of Biochemistry, University of Oxford, Oxford, United Kingdom

Rafael Ufret-Vincenty

Affiliation Department of Ophthalmology, UT Southwestern Medical Center, Dallas, Texas, United States of America

Ray Borrow

Affiliation Vaccine Evaluation Unit, Public Health Laboratory, Manchester Medical Microbiology Partnership, Manchester, United Kingdom

Matthew C. Pickering

m.pickering@imperial.ac.uk (MCP); susan.lea@path.ox.ac.uk (SML); christoph.tang@path.ox.ac.uk (CMT)

Affiliation Centre for Complement and Inflammation Research (CCIR), Department of Medicine, Imperial College, London, United Kingdom

Susan M. Lea

m.pickering@imperial.ac.uk (MCP); susan.lea@path.ox.ac.uk (SML); christoph.tang@path.ox.ac.uk (CMT)

Affiliation Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom

Christoph M. Tang

m.pickering@imperial.ac.uk (MCP); susan.lea@path.ox.ac.uk (SML); christoph.tang@path.ox.ac.uk (CMT)

Affiliations Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom, Centre for Molecular Microbiology and Infection, Imperial College, London, United Kingdom

Competing Interests

Work in CMT's and SML's laboratories is funded by Novartis. This does not alter our adherence to all PLoS Pathogens policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SJ RME RB MCP SML CMT. Performed the experiments: SJ LT SvdV JC EGJ RJH XB PNW NR KT EC RJ LN DS RME. Analyzed the data: SJ LT SvdV JC EGJ RJH XB PNW NR KT EC RJ LN DS RB MCP SML CMT. Contributed reagents/materials/analysis tools: RU-V. Wrote the paper: SJ EGJ RJH CMT.