HPV 5 and 8 E6 Abrogate ATR Activity Resulting in Increased Persistence of UVB Induced DNA Damage

Nicholas A. Wallace; Kristin Robinson; Heather L. Howie; Denise A. Galloway

doi:10.1371/journal.ppat.1002807

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Open Access

Peer-reviewed

Research Article

HPV 5 and 8 E6 Abrogate ATR Activity Resulting in Increased Persistence of UVB Induced DNA Damage

Nicholas A. Wallace,

Affiliation Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Kristin Robinson,

Affiliation Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Heather L. Howie,

Affiliation Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Denise A. Galloway

* E-mail: dgallowa@fhcrc.org

Affiliation Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯

HPV 5 and 8 E6 Abrogate ATR Activity Resulting in Increased Persistence of UVB Induced DNA Damage

Nicholas A. Wallace,
Kristin Robinson,
Heather L. Howie,
Denise A. Galloway

Published: July 12, 2012
https://doi.org/10.1371/journal.ppat.1002807

About the Authors

Nicholas A. Wallace

Affiliation Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

Kristin Robinson

Affiliation Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

Heather L. Howie

Affiliation Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

Denise A. Galloway

* E-mail: dgallowa@fhcrc.org

Affiliation Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NAW KR HLH DAG. Performed the experiments: NAW KR HLH. Analyzed the data: NAW HLH. Contributed reagents/materials/analysis tools: DAG. Wrote the paper: NAW DAG.

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Thymine
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HT1080 cells
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Human papillomavirus
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DNA damage
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Phosphorylation
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DNA repair
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Immunoblotting
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Gene expression
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