The Cholesterol-Dependent Cytolysin Signature Motif: A Critical Element in the Allosteric Pathway that Couples Membrane Binding to Pore Assembly

Kelley J. Dowd; Rodney K. Tweten

doi:10.1371/journal.ppat.1002787

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Open Access

Peer-reviewed

Research Article

The Cholesterol-Dependent Cytolysin Signature Motif: A Critical Element in the Allosteric Pathway that Couples Membrane Binding to Pore Assembly

Kelley J. Dowd,

Affiliation Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America
⨯
Rodney K. Tweten

* E-mail: Rodney-Tweten@ouhsc.edu

Affiliation Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America
⨯

The Cholesterol-Dependent Cytolysin Signature Motif: A Critical Element in the Allosteric Pathway that Couples Membrane Binding to Pore Assembly

Kelley J. Dowd,
Rodney K. Tweten

Published: July 5, 2012
https://doi.org/10.1371/journal.ppat.1002787

About the Authors

Kelley J. Dowd

Affiliation Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America

Rodney K. Tweten

* E-mail: Rodney-Tweten@ouhsc.edu

Affiliation Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KJD RKT. Performed the experiments: KJD. Analyzed the data: KJD RKT. Contributed reagents/materials/analysis tools: KJD RKT. Wrote the paper: KJD RKT.

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Monomers
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Crystal structure
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Fluorescence
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Toxins
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Liposomes
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Cholesterol
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Cell membranes
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