About the Authors

Amy Huei-Yi Lee

Affiliations Department of Cell & Systems Biology, University of Toronto, Toronto, Ontario, Canada, Centre for the Analysis of Genome Evolution & Function, University of Toronto, Toronto, Ontario, Canada

Brenden Hurley

Affiliation Department of Cell & Systems Biology, University of Toronto, Toronto, Ontario, Canada

Corinna Felsensteiner

Affiliation Centre for the Analysis of Genome Evolution & Function, University of Toronto, Toronto, Ontario, Canada

Carmen Yea

Affiliation Department of Cell & Systems Biology, University of Toronto, Toronto, Ontario, Canada

Wenzislava Ckurshumova

Affiliation Department of Cell & Systems Biology, University of Toronto, Toronto, Ontario, Canada

Verena Bartetzko

Affiliation Institut für Biologie, Lehrstuhl für Biochemie, Friedrich Alexander Universität Erlangen-Nürnberg, Germany

Pauline W. Wang

Affiliation Centre for the Analysis of Genome Evolution & Function, University of Toronto, Toronto, Ontario, Canada

Van Quach

Affiliation Department of Cell & Systems Biology, University of Toronto, Toronto, Ontario, Canada

Jennifer D. Lewis

Affiliation Department of Cell & Systems Biology, University of Toronto, Toronto, Ontario, Canada

Yulu C. Liu

Affiliation Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada

Frederik Börnke

Affiliation Institut für Biologie, Lehrstuhl für Biochemie, Friedrich Alexander Universität Erlangen-Nürnberg, Germany

Stephane Angers

Affiliations Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada, Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada

Andrew Wilde

Affiliations Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

David S. Guttman

Contributed equally to this work with: David S. Guttman, Darrell Desveaux

david.guttman@utoronto.ca (DSG); darrell.desveaux@utoronto.ca (DD)

Affiliations Department of Cell & Systems Biology, University of Toronto, Toronto, Ontario, Canada, Centre for the Analysis of Genome Evolution & Function, University of Toronto, Toronto, Ontario, Canada

Darrell Desveaux

Contributed equally to this work with: David S. Guttman, Darrell Desveaux

david.guttman@utoronto.ca (DSG); darrell.desveaux@utoronto.ca (DD)

Affiliations Department of Cell & Systems Biology, University of Toronto, Toronto, Ontario, Canada, Centre for the Analysis of Genome Evolution & Function, University of Toronto, Toronto, Ontario, Canada

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AH-YL BH DD DSG AW SA FB. Performed the experiments: AH-YL BH CF CY WC VB PWW YCL SA. Analyzed the data: AH-YL BH CF DD DSG AW SA VB FB. Contributed reagents/materials/analysis tools: VQ JDL. Wrote the paper: AH-YL DD DSG.