The TPR Domain in the Host Cyp40-like Cyclophilin Binds to the Viral Replication Protein and Inhibits the Assembly of the Tombusviral Replicase

Jing-Yi Lin; Venugopal Mendu; Judit Pogany; Jun Qin; Peter D. Nagy

doi:10.1371/journal.ppat.1002491

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Peer-reviewed

Research Article

The TPR Domain in the Host Cyp40-like Cyclophilin Binds to the Viral Replication Protein and Inhibits the Assembly of the Tombusviral Replicase

Jing-Yi Lin,

Affiliation Department of Plant Pathology, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Venugopal Mendu ,

Contributed equally to this work with: Venugopal Mendu, Judit Pogany

Affiliation Department of Plant Pathology, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Judit Pogany ,

Contributed equally to this work with: Venugopal Mendu, Judit Pogany

Affiliation Department of Plant Pathology, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Jun Qin,

Current address: College of Life Science, Northwest A&F University, Yangling, Shaanxi, People's Republic of China

Affiliation Department of Plant Pathology, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Peter D. Nagy

* E-mail: pdnagy2@uky.edu

Affiliation Department of Plant Pathology, University of Kentucky, Lexington, Kentucky, United States of America
⨯

The TPR Domain in the Host Cyp40-like Cyclophilin Binds to the Viral Replication Protein and Inhibits the Assembly of the Tombusviral Replicase

Jing-Yi Lin,
Venugopal Mendu,
Judit Pogany,
Jun Qin,
Peter D. Nagy

Published: February 9, 2012
https://doi.org/10.1371/journal.ppat.1002491

About the Authors

Jing-Yi Lin

Affiliation Department of Plant Pathology, University of Kentucky, Lexington, Kentucky, United States of America

Venugopal Mendu

Contributed equally to this work with: Venugopal Mendu, Judit Pogany

Affiliation Department of Plant Pathology, University of Kentucky, Lexington, Kentucky, United States of America

Judit Pogany

Contributed equally to this work with: Venugopal Mendu, Judit Pogany

Affiliation Department of Plant Pathology, University of Kentucky, Lexington, Kentucky, United States of America

Jun Qin

Current address: College of Life Science, Northwest A&F University, Yangling, Shaanxi, People's Republic of China

Affiliation Department of Plant Pathology, University of Kentucky, Lexington, Kentucky, United States of America

Peter D. Nagy

* E-mail: pdnagy2@uky.edu

Affiliation Department of Plant Pathology, University of Kentucky, Lexington, Kentucky, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JYL JP PDN. Performed the experiments: JYL VM JQ. Analyzed the data: JYL VM PDN. Contributed reagents/materials/analysis tools: VM JP. Wrote the paper: JYL PDN.

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Viral replication
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Yeast
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RNA synthesis
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RNA-binding proteins
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Recombinant protein purification
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Saccharomyces cerevisiae
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Protein domains
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RNA viruses
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