Autophagy Protein Atg3 is Essential for Maintaining Mitochondrial Integrity and for Normal Intracellular Development of Toxoplasma gondii Tachyzoites

Sébastien Besteiro; Carrie F. Brooks; Boris Striepen; Jean-François Dubremetz

doi:10.1371/journal.ppat.1002416

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Open Access

Peer-reviewed

Research Article

Autophagy Protein Atg3 is Essential for Maintaining Mitochondrial Integrity and for Normal Intracellular Development of Toxoplasma gondii Tachyzoites

Sébastien Besteiro ,

* E-mail: sebastien.besteiro@univ-montp2.fr

Affiliations UMR 5235 CNRS, Universités de Montpellier 2 et 1, Dynamique des Interactions Membranaires Normales et Pathologiques, Montpellier, France, INSERM, Dynamique des Interactions Membranaires Normales et Pathologiques, Montpellier, France
⨯
Carrie F. Brooks,

Affiliation Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America
⨯
Boris Striepen,

Affiliation Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America
⨯
Jean-François Dubremetz

Affiliation UMR 5235 CNRS, Universités de Montpellier 2 et 1, Dynamique des Interactions Membranaires Normales et Pathologiques, Montpellier, France
⨯

Autophagy Protein Atg3 is Essential for Maintaining Mitochondrial Integrity and for Normal Intracellular Development of Toxoplasma gondii Tachyzoites

Sébastien Besteiro,
Carrie F. Brooks,
Boris Striepen,
Jean-François Dubremetz

Published: December 1, 2011
https://doi.org/10.1371/journal.ppat.1002416

About the Authors

Sébastien Besteiro

* E-mail: sebastien.besteiro@univ-montp2.fr

Affiliations UMR 5235 CNRS, Universités de Montpellier 2 et 1, Dynamique des Interactions Membranaires Normales et Pathologiques, Montpellier, France, INSERM, Dynamique des Interactions Membranaires Normales et Pathologiques, Montpellier, France

Carrie F. Brooks

Affiliation Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America

Boris Striepen

Affiliation Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America

Jean-François Dubremetz

Affiliation UMR 5235 CNRS, Universités de Montpellier 2 et 1, Dynamique des Interactions Membranaires Normales et Pathologiques, Montpellier, France

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SB. Performed the experiments: SB JFD. Analyzed the data: SB JFD. Contributed reagents/materials/analysis tools: CFB BS. Wrote the paper: SB BS.

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Tachyzoites
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Autophagic cell death
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Toxoplasma gondii
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Cellular structures and organelles
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Mitochondria
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Vesicles
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Immunoprecipitation
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Urea
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