The Enteropathogenic E. coli (EPEC) Tir Effector Inhibits NF-κB Activity by Targeting TNFα Receptor-Associated Factors

Marie-Hélène Ruchaud-Sparagano; Sabrina Mühlen; Paul Dean; Brendan Kenny

doi:10.1371/journal.ppat.1002414

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Open Access

Peer-reviewed

Research Article

The Enteropathogenic E. coli (EPEC) Tir Effector Inhibits NF-κB Activity by Targeting TNFα Receptor-Associated Factors

Marie-Hélène Ruchaud-Sparagano,

Affiliation Institute for Cell and Molecular Biosciences, Medical School, Newcastle University, Newcastle-upon-Tyne, United Kingdom
⨯
Sabrina Mühlen,

Affiliation Institute for Cell and Molecular Biosciences, Medical School, Newcastle University, Newcastle-upon-Tyne, United Kingdom
⨯
Paul Dean,

Affiliation Institute for Cell and Molecular Biosciences, Medical School, Newcastle University, Newcastle-upon-Tyne, United Kingdom
⨯
Brendan Kenny

* E-mail: brendan.kenny@ncl.ac.uk

Affiliation Institute for Cell and Molecular Biosciences, Medical School, Newcastle University, Newcastle-upon-Tyne, United Kingdom
⨯

The Enteropathogenic E. coli (EPEC) Tir Effector Inhibits NF-κB Activity by Targeting TNFα Receptor-Associated Factors

Marie-Hélène Ruchaud-Sparagano,
Sabrina Mühlen,
Paul Dean,
Brendan Kenny

Published: December 1, 2011
https://doi.org/10.1371/journal.ppat.1002414

About the Authors

Marie-Hélène Ruchaud-Sparagano

Affiliation Institute for Cell and Molecular Biosciences, Medical School, Newcastle University, Newcastle-upon-Tyne, United Kingdom

Sabrina Mühlen

Affiliation Institute for Cell and Molecular Biosciences, Medical School, Newcastle University, Newcastle-upon-Tyne, United Kingdom

Paul Dean

Affiliation Institute for Cell and Molecular Biosciences, Medical School, Newcastle University, Newcastle-upon-Tyne, United Kingdom

Brendan Kenny

* E-mail: brendan.kenny@ncl.ac.uk

Affiliation Institute for Cell and Molecular Biosciences, Medical School, Newcastle University, Newcastle-upon-Tyne, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: M-HR-S SM PD BK. Performed the experiments: M-HR-S SM PD. Analyzed the data: M-HR-S SM PD BK. Contributed reagents/materials/analysis tools: M-HR-S SM PD. Wrote the paper: BK.

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HeLa cells
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Signal inhibition
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Secretion
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Transfection
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Immune receptor signaling
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Bacterial pathogens
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