Elevated 17β-Estradiol Protects Females from Influenza A Virus Pathogenesis by Suppressing Inflammatory Responses

Dionne P. Robinson; Maria E. Lorenzo; William Jian; Sabra L. Klein

doi:10.1371/journal.ppat.1002149

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Peer-reviewed

Research Article

Elevated 17β-Estradiol Protects Females from Influenza A Virus Pathogenesis by Suppressing Inflammatory Responses

Dionne P. Robinson,

Affiliation W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
⨯
Maria E. Lorenzo,

Affiliation W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
⨯
William Jian,

Affiliation W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
⨯
Sabra L. Klein

* E-mail: saklein@jhsph.edu

Affiliation W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
⨯

Elevated 17β-Estradiol Protects Females from Influenza A Virus Pathogenesis by Suppressing Inflammatory Responses

Dionne P. Robinson,
Maria E. Lorenzo,
William Jian,
Sabra L. Klein

Published: July 28, 2011
https://doi.org/10.1371/journal.ppat.1002149

About the Authors

Dionne P. Robinson

Affiliation W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

Maria E. Lorenzo

Affiliation W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

William Jian

Affiliation W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

Sabra L. Klein

* E-mail: saklein@jhsph.edu

Affiliation W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DPR SLK. Performed the experiments: DPR MEL WJ. Analyzed the data: DPR SLK. Wrote the paper: DPR SLK.

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Influenza
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Influenza viruses
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Influenza A virus
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Viral pathogens
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Pathogenesis
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Cytokines
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Morbidity
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Pathogens
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