Botulinum Neurotoxin D Uses Synaptic Vesicle Protein SV2 and Gangliosides as Receptors

Lisheng Peng; William H. Tepp; Eric A. Johnson; Min Dong

doi:10.1371/journal.ppat.1002008

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Open Access

Peer-reviewed

Research Article

Botulinum Neurotoxin D Uses Synaptic Vesicle Protein SV2 and Gangliosides as Receptors

Lisheng Peng,

Affiliation Department of Microbiology and Molecular Genetics, Harvard Medical School and Division of Neuroscience, New England Primate Research Center, Southborough, Massachusetts, United States of America
⨯
William H. Tepp,

Affiliation Department of Food Microbiology and Toxicology, University of Wisconsin, Madison, Wisconsin, United States of America
⨯
Eric A. Johnson,

Affiliation Department of Food Microbiology and Toxicology, University of Wisconsin, Madison, Wisconsin, United States of America
⨯
Min Dong

* E-mail: min_dong@hms.harvard.edu

Affiliation Department of Microbiology and Molecular Genetics, Harvard Medical School and Division of Neuroscience, New England Primate Research Center, Southborough, Massachusetts, United States of America
⨯

Botulinum Neurotoxin D Uses Synaptic Vesicle Protein SV2 and Gangliosides as Receptors

Lisheng Peng,
William H. Tepp,
Eric A. Johnson,
Min Dong

Published: March 31, 2011
https://doi.org/10.1371/journal.ppat.1002008

About the Authors

Lisheng Peng

Affiliation Department of Microbiology and Molecular Genetics, Harvard Medical School and Division of Neuroscience, New England Primate Research Center, Southborough, Massachusetts, United States of America

William H. Tepp

Affiliation Department of Food Microbiology and Toxicology, University of Wisconsin, Madison, Wisconsin, United States of America

Eric A. Johnson

Affiliation Department of Food Microbiology and Toxicology, University of Wisconsin, Madison, Wisconsin, United States of America

Min Dong

* E-mail: min_dong@hms.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LP MD. Performed the experiments: LP WHT MD. Analyzed the data: LP WHT MD. Contributed reagents/materials/analysis tools: WHT EAJ. Wrote the paper: LP MD.

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Neurons
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Toxins
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Sphingolipids
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Immunostaining
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Synaptic vesicles
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Hippocampus
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Membrane proteins
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Cell binding
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