About the Authors

Wade S. Blair

Contributed equally to this work with: Wade S. Blair, Chris Pickford

Current address: Biochemical Pharmacology Department, Genentech Inc., South San Francisco, California, United States of America

Affiliation Pfizer Global Research and Development, La Jolla Laboratories, San Diego, California, United States of America

Chris Pickford

Contributed equally to this work with: Wade S. Blair, Chris Pickford

Affiliation Antiviral Biology, Pfizer Global Research and Development, Sandwich, Kent, United Kingdom

Stephen L. Irving

Affiliation Structural Biology Department, Pfizer Global Research and Development, Sandwich, Kent, United Kingdom

David G. Brown

Affiliation Structural Biology Department, Pfizer Global Research and Development, Sandwich, Kent, United Kingdom

Marie Anderson

Affiliation Structural Biology Department, Pfizer Global Research and Development, Sandwich, Kent, United Kingdom

Richard Bazin

Affiliation Structural Biology Department, Pfizer Global Research and Development, Sandwich, Kent, United Kingdom

Joan Cao

Affiliation Pfizer Global Research and Development, La Jolla Laboratories, San Diego, California, United States of America

Giuseppe Ciaramella

Affiliation Antiviral Biology, Pfizer Global Research and Development, Sandwich, Kent, United Kingdom

Jason Isaacson

Affiliation Pfizer Global Research and Development, La Jolla Laboratories, San Diego, California, United States of America

Lynn Jackson

Current address: School of Medicine, University of California San Diego, San Diego, California, United States of America

Affiliation Pfizer Global Research and Development, La Jolla Laboratories, San Diego, California, United States of America

Rachael Hunt

Affiliation Antiviral Biology, Pfizer Global Research and Development, Sandwich, Kent, United Kingdom

Anne Kjerrstrom

Affiliation Antiviral Biology, Pfizer Global Research and Development, Sandwich, Kent, United Kingdom

James A. Nieman

Current address: NAEJA Pharmaceuticals Inc., Edmonton, Alberta, Canada

Affiliation Pfizer Global Research and Development, La Jolla Laboratories, San Diego, California, United States of America

Amy K. Patick

Current address: Adamas Pharmaceuticals, Emeryville, California, United States of America

Affiliation Pfizer Global Research and Development, La Jolla Laboratories, San Diego, California, United States of America

Manos Perros

Current address: Novartis Institute for Tropical Diseases, Singapore

Affiliation Antiviral Biology, Pfizer Global Research and Development, Sandwich, Kent, United Kingdom

Andrew D. Scott

Affiliation Structural Biology Department, Pfizer Global Research and Development, Sandwich, Kent, United Kingdom

Kevin Whitby

Affiliation Antiviral Biology, Pfizer Global Research and Development, Sandwich, Kent, United Kingdom

Hua Wu

Affiliation Pfizer Global Research and Development, La Jolla Laboratories, San Diego, California, United States of America

Scott L. Butler

scott.butler@pfizer.com

Affiliation Antiviral Biology, Pfizer Global Research and Development, Sandwich, Kent, United Kingdom

Competing Interests

CP, SLI, DGB, MA, RB, JC, GC, JI, RH, KW, HW, and SLB are employed by Pfizer, which carries out research and development of antiretrovirals for HIV.

Author Contributions

Conceived and designed the experiments: WSB CP SLB. Performed the experiments: SLI MA RB JC JI LJ RH AK JAN ADS KW HW. Analyzed the data: WSB CP DGB GC AKP MP KW SLB. Wrote the paper: WSB CP SLI SLB.