About the Authors

Tannistha Nandi

Affiliation Genome Institute of Singapore, Singapore, Republic of Singapore

Catherine Ong

Affiliation Defense Medical and Environmental Research Institute, DSO National Laboratories, Singapore, Republic of Singapore

Arvind Pratap Singh

Affiliation Genome Institute of Singapore, Singapore, Republic of Singapore

Justin Boddey

Affiliation Institute for Glycomics, Griffith University (Gold Coast Campus), Southport, Queensland, Australia

Timothy Atkins

Affiliation Defence Science and Technology Laboratory, Porton Down, Salisbury, United Kingdom

Mitali Sarkar-Tyson

Affiliation Defence Science and Technology Laboratory, Porton Down, Salisbury, United Kingdom

Angela E. Essex-Lopresti

Affiliation Defence Science and Technology Laboratory, Porton Down, Salisbury, United Kingdom

Hui Hoon Chua

Affiliation Genome Institute of Singapore, Singapore, Republic of Singapore

Talima Pearson

Affiliation Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona, United States of America

Jason F. Kreisberg

Affiliation Genome Institute of Singapore, Singapore, Republic of Singapore

Christina Nilsson

Affiliation Genome Institute of Singapore, Singapore, Republic of Singapore

Pramila Ariyaratne

Affiliation Genome Institute of Singapore, Singapore, Republic of Singapore

Catherine Ronning

Affiliation J. Craig Venter Institute, Rockville, Maryland, United States of America

Liliana Losada

Affiliation J. Craig Venter Institute, Rockville, Maryland, United States of America

Yijun Ruan

Affiliation Genome Institute of Singapore, Singapore, Republic of Singapore

Wing-Kin Sung

Affiliation Genome Institute of Singapore, Singapore, Republic of Singapore

Donald Woods

Affiliation Faculty of Medicine, University of Calgary Health Sciences Centre, Calgary, Alberta, Canada

Richard W. Titball

Affiliations Defence Science and Technology Laboratory, Porton Down, Salisbury, United Kingdom, School of Biosciences, University of Exeter, Exeter, United Kingdom

Ifor Beacham

Affiliation Institute for Glycomics, Griffith University (Gold Coast Campus), Southport, Queensland, Australia

Ian Peak

Affiliation Institute for Glycomics, Griffith University (Gold Coast Campus), Southport, Queensland, Australia

Paul Keim

Affiliation Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona, United States of America

William C. Nierman

wnierman@jcvi.org (WCN); tanbop@gis.a-star.edu.sg (PT)

Affiliation J. Craig Venter Institute, Rockville, Maryland, United States of America

Patrick Tan

wnierman@jcvi.org (WCN); tanbop@gis.a-star.edu.sg (PT)

Affiliations Genome Institute of Singapore, Singapore, Republic of Singapore, Duke-NUS Graduate Medical School Singapore, Singapore, Republic of Singapore

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TN TA JFK RWT IB IP PT. Performed the experiments: CO APS JB MST AEEL HHC. Analyzed the data: TN JB TP PA CR LL WKS WCN PT. Contributed reagents/materials/analysis tools: CN YR DW PK WCN. Wrote the paper: TN PT. Performed the major analyses, and drafted the manuscript and figures: TN. Performed the tiling-array and taurine utilization experiments: CO. Performed the cell culture experiments: APS. Performed the PCR and sequencing validation experiments: HHC. Provided strains for genome sequencing: DW. Coordinated the construction of isogenic mutants and murine virulence assays: RWT IB IP. Provided supporting data for the SNP analysis: PK. Conceived the study: TN PT. Participated in the design and coordination of the study and manuscript preparation: PT.