Mucosal Lipocalin 2 Has Pro-Inflammatory and Iron-Sequestering Effects in Response to Bacterial Enterobactin

Michael A. Bachman; Virginia L. Miller; Jeffrey N. Weiser

doi:10.1371/journal.ppat.1000622

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Open Access

Peer-reviewed

Research Article

Mucosal Lipocalin 2 Has Pro-Inflammatory and Iron-Sequestering Effects in Response to Bacterial Enterobactin

Michael A. Bachman,

Affiliations Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Virginia L. Miller,

Affiliations Department of Genetics, The University of North Carolina, Chapel Hill, North Carolina, United States of America, Department of Microbiology and Immunology, The University of North Carolina, Chapel Hill, North Carolina, United States of America
⨯
Jeffrey N. Weiser

* E-mail: weiser@mail.med.upenn.edu

Affiliations Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯

Mucosal Lipocalin 2 Has Pro-Inflammatory and Iron-Sequestering Effects in Response to Bacterial Enterobactin

Michael A. Bachman,
Virginia L. Miller,
Jeffrey N. Weiser

Published: October 16, 2009
https://doi.org/10.1371/journal.ppat.1000622

About the Authors

Michael A. Bachman

Affiliations Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Virginia L. Miller

Affiliations Department of Genetics, The University of North Carolina, Chapel Hill, North Carolina, United States of America, Department of Microbiology and Immunology, The University of North Carolina, Chapel Hill, North Carolina, United States of America

Jeffrey N. Weiser

* E-mail: weiser@mail.med.upenn.edu

Affiliations Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MAB JNW. Performed the experiments: MAB. Analyzed the data: MAB. Contributed reagents/materials/analysis tools: VM. Wrote the paper: MAB VM JNW.

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Klebsiella pneumoniae
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Neutrophils
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Bacterial pathogens
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Inflammation
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Pneumonia
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Nasopharynx
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Flow cytometry
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