Rapid Influx and Death of Plasmacytoid Dendritic Cells in Lymph Nodes Mediate Depletion in Acute Simian Immunodeficiency Virus Infection

Kevin N. Brown; Viskam Wijewardana; Xiangdong Liu; Simon M. Barratt-Boyes

doi:10.1371/journal.ppat.1000413

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Peer-reviewed

Research Article

Rapid Influx and Death of Plasmacytoid Dendritic Cells in Lymph Nodes Mediate Depletion in Acute Simian Immunodeficiency Virus Infection

Kevin N. Brown,

Affiliations Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Viskam Wijewardana,

Affiliation Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Xiangdong Liu,

Affiliation Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Simon M. Barratt-Boyes

* E-mail: smbb@pitt.edu

Affiliations Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯

Rapid Influx and Death of Plasmacytoid Dendritic Cells in Lymph Nodes Mediate Depletion in Acute Simian Immunodeficiency Virus Infection

Kevin N. Brown,
Viskam Wijewardana,
Xiangdong Liu,
Simon M. Barratt-Boyes

Published: May 8, 2009
https://doi.org/10.1371/journal.ppat.1000413

About the Authors

Kevin N. Brown

Affiliations Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Viskam Wijewardana

Affiliation Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Xiangdong Liu

Affiliation Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Simon M. Barratt-Boyes

* E-mail: smbb@pitt.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KNB VW SMBB. Performed the experiments: KNB VW XL. Analyzed the data: KNB VW XL SMBB. Wrote the paper: KNB SMBB.

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Lymph nodes
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SIV
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Blood
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Macaque
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T cells
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