Likely Role of APOBEC3G-Mediated G-to-A Mutations in HIV-1 Evolution and Drug Resistance

Patric Jern; Rebecca A. Russell; Vinay K. Pathak; John M. Coffin

doi:10.1371/journal.ppat.1000367

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Open Access

Peer-reviewed

Research Article

Likely Role of APOBEC3G-Mediated G-to-A Mutations in HIV-1 Evolution and Drug Resistance

Patric Jern,

Affiliation Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, United States of America
⨯
Rebecca A. Russell,

Affiliation HIV Drug Resistance Program, National Cancer Institute-Frederick, Frederick, Maryland, United States of America
⨯
Vinay K. Pathak,

Affiliation HIV Drug Resistance Program, National Cancer Institute-Frederick, Frederick, Maryland, United States of America
⨯
John M. Coffin

* E-mail: john.coffin@tufts.edu

Affiliation Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, United States of America
⨯

Likely Role of APOBEC3G-Mediated G-to-A Mutations in HIV-1 Evolution and Drug Resistance

Patric Jern,
Rebecca A. Russell,
Vinay K. Pathak,
John M. Coffin

Published: April 3, 2009
https://doi.org/10.1371/journal.ppat.1000367

About the Authors

Patric Jern

Affiliation Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, United States of America

Rebecca A. Russell

Affiliation HIV Drug Resistance Program, National Cancer Institute-Frederick, Frederick, Maryland, United States of America

Vinay K. Pathak

Affiliation HIV Drug Resistance Program, National Cancer Institute-Frederick, Frederick, Maryland, United States of America

John M. Coffin

* E-mail: john.coffin@tufts.edu

Affiliation Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PJ JMC. Performed the experiments: PJ RAR JMC. Analyzed the data: PJ JMC. Contributed reagents/materials/analysis tools: PJ RAR VP JMC. Wrote the paper: PJ RAR VP JMC.

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HIV-1
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Viral evolution
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Microbial mutation
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Mutation databases
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Probability distribution
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Nonsense mutation
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Deletion mutation
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Genetic footprinting
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