Rotavirus NSP1 Inhibits NFκB Activation by Inducing Proteasome-Dependent Degradation of β-TrCP: A Novel Mechanism of IFN Antagonism

Open Access

Peer-reviewed

Research Article

About the Authors

Joel W. Graff

Contributed equally to this work with: Joel W. Graff, Khalil Ettayebi

Affiliation Veterinary Molecular Biology, Montana State University, Bozeman, Montana, United States of America

Khalil Ettayebi

Contributed equally to this work with: Joel W. Graff, Khalil Ettayebi

Affiliation Veterinary Molecular Biology, Montana State University, Bozeman, Montana, United States of America

Michele E. Hardy

* E-mail: mhardy@montana.edu

Affiliation Veterinary Molecular Biology, Montana State University, Bozeman, Montana, United States of America

The authors have declared that no competing interests exist.

Conceived and designed the experiments: JWG KE MEH. Performed the experiments: JWG KE. Analyzed the data: JWG KE MEH. Wrote the paper: JWG KE MEH.

Rotavirus infection
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Interferons
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Immunoprecipitation
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Proteasomes
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Transfection
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Immunoblotting
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Ligases
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Phosphorylation
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