Crystal Structure of Botulinum Neurotoxin Type A in Complex with the Cell Surface Co-Receptor GT1b—Insight into the Toxin–Neuron Interaction

Pål Stenmark; Jérôme Dupuy; Akihiro Imamura; Makoto Kiso; Raymond C. Stevens

doi:10.1371/journal.ppat.1000129

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Open Access

Peer-reviewed

Research Article

Crystal Structure of Botulinum Neurotoxin Type A in Complex with the Cell Surface Co-Receptor GT1b—Insight into the Toxin–Neuron Interaction

Pål Stenmark ,

Contributed equally to this work with: Pål Stenmark, Jérôme Dupuy

Affiliation Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America
⨯
Jérôme Dupuy ,

Contributed equally to this work with: Pål Stenmark, Jérôme Dupuy

Affiliation Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America
⨯
Akihiro Imamura,

Affiliation Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Yoshida, Sakyo-ku, Kyoto, Japan
⨯
Makoto Kiso,

Affiliation Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Yoshida, Sakyo-ku, Kyoto, Japan
⨯
Raymond C. Stevens

* E-mail: stevens@scripps.edu

Affiliation Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America
⨯

Crystal Structure of Botulinum Neurotoxin Type A in Complex with the Cell Surface Co-Receptor GT1b—Insight into the Toxin–Neuron Interaction

Pål Stenmark,
Jérôme Dupuy,
Akihiro Imamura,
Makoto Kiso,
Raymond C. Stevens

Published: August 15, 2008
https://doi.org/10.1371/journal.ppat.1000129

About the Authors

Pål Stenmark

Contributed equally to this work with: Pål Stenmark, Jérôme Dupuy

Affiliation Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America

Jérôme Dupuy

Contributed equally to this work with: Pål Stenmark, Jérôme Dupuy

Affiliation Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America

Akihiro Imamura

Affiliation Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Yoshida, Sakyo-ku, Kyoto, Japan

Makoto Kiso

Affiliation Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Yoshida, Sakyo-ku, Kyoto, Japan

Raymond C. Stevens

* E-mail: stevens@scripps.edu

Affiliation Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PS JD RCS. Performed the experiments: PS JD. Analyzed the data: PS RCS. Contributed reagents/materials/analysis tools: AI MK. Wrote the paper: PS RCS.

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Sphingolipids
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Toxins
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Crystal structure
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Hydrogen bonding
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Coreceptors
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Protein structure
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Neurotoxins
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Botulinum toxin
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