TRIM E3 Ligases Interfere with Early and Late Stages of the Retroviral Life Cycle

Open Access

Peer-reviewed

Research Article

Pradeep D Uchil ,

Contributed equally to this work with: Pradeep D Uchil, Brian D Quinlan

Affiliation Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Brian D Quinlan ,

Contributed equally to this work with: Pradeep D Uchil, Brian D Quinlan

Affiliation Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Wai-Tsing Chan,

Affiliation Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Joseph M Luna,

Affiliation Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Walther Mothes

*To whom correspondence should be addressed. E-mail: walther.mothes@yale.edu

Affiliation Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯

About the Authors

Pradeep D Uchil

Contributed equally to this work with: Pradeep D Uchil, Brian D Quinlan

Affiliation Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States of America

Brian D Quinlan

Contributed equally to this work with: Pradeep D Uchil, Brian D Quinlan

Affiliation Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States of America

Wai-Tsing Chan

Affiliation Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States of America

Joseph M Luna

Affiliation Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States of America

Walther Mothes

*To whom correspondence should be addressed. E-mail: walther.mothes@yale.edu

Affiliation Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States of America

The authors have declared that no competing interests exist.

PDU, BDQ, and WM designed the study. PDU and BDQ performed all experiments with some assistance from WTC and JML. PDU and WM wrote the manuscript.

HIV
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Transfection
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Protein expression
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Viral gene expression
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Small interfering RNA
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Viral packaging
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Plasmid construction
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Retroviruses
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