A Functional Genomic Yeast Screen to Identify Pathogenic Bacterial Proteins

Naomi L Slagowski; Roger W Kramer; Monica F Morrison; Joshua LaBaer; Cammie F Lesser

doi:10.1371/journal.ppat.0040009

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Open Access

Peer-reviewed

Research Article

A Functional Genomic Yeast Screen to Identify Pathogenic Bacterial Proteins

Naomi L Slagowski,

Affiliation Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Cambridge, Massachusetts, United States of America
⨯
Roger W Kramer,

Affiliation Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Cambridge, Massachusetts, United States of America
⨯
Monica F Morrison,

Affiliation Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Cambridge, Massachusetts, United States of America
⨯
Joshua LaBaer,

Affiliation Harvard Institute of Proteomics, Harvard Medical School, Cambridge, Massachusetts, United States of America
⨯
Cammie F Lesser

*To whom correspondence should be addressed. E-mail: clesser@rics.bwh.harvard.edu

Affiliation Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Cambridge, Massachusetts, United States of America
⨯

A Functional Genomic Yeast Screen to Identify Pathogenic Bacterial Proteins

Naomi L Slagowski,
Roger W Kramer,
Monica F Morrison,
Joshua LaBaer,
Cammie F Lesser

Published: January 18, 2008
https://doi.org/10.1371/journal.ppat.0040009

About the Authors

Naomi L Slagowski

Affiliation Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Cambridge, Massachusetts, United States of America

Roger W Kramer

Affiliation Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Cambridge, Massachusetts, United States of America

Monica F Morrison

Affiliation Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Cambridge, Massachusetts, United States of America

Joshua LaBaer

Affiliation Harvard Institute of Proteomics, Harvard Medical School, Cambridge, Massachusetts, United States of America

Cammie F Lesser

*To whom correspondence should be addressed. E-mail: clesser@rics.bwh.harvard.edu

Affiliation Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Cambridge, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

NLS, RWK, MFM, and CFL conceived of and designed the experiments. NLS, MFM, and CFL performed the experiments. NLS, RWK, and CFL analyzed the data. RWK and JL contributed reagents/materials/analysis tools. RWK and CFL wrote the paper.

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Yeast
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Saccharomyces cerevisiae
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Shigella
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Protein expression
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Francisella
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Francisella tularensis
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Phenotypes
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Bacterial pathogens
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