A Single Mutation in the PB1-F2 of H5N1 (HK/97) and 1918 Influenza A Viruses Contributes to Increased Virulence

Gina M Conenello; Dmitriy Zamarin; Lucy A Perrone; Terrence Tumpey; Peter Palese

doi:10.1371/journal.ppat.0030141

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Open Access

Peer-reviewed

Research Article

A Single Mutation in the PB1-F2 of H5N1 (HK/97) and 1918 Influenza A Viruses Contributes to Increased Virulence

Gina M Conenello,

Affiliation Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America
⨯
Dmitriy Zamarin,

Affiliation Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America
⨯
Lucy A Perrone,

Affiliation Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
⨯
Terrence Tumpey,

Affiliation Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
⨯
Peter Palese

*To whom correspondence should be addressed. E-mail: peter.palese@mssm.edu

Affiliations Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America , Department of Medicine, Mount Sinai School of Medicine, New York, New York, United States of America
⨯

A Single Mutation in the PB1-F2 of H5N1 (HK/97) and 1918 Influenza A Viruses Contributes to Increased Virulence

Gina M Conenello,
Dmitriy Zamarin,
Lucy A Perrone,
Terrence Tumpey,
Peter Palese

Published: October 5, 2007
https://doi.org/10.1371/journal.ppat.0030141

About the Authors

Gina M Conenello

Affiliation Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America

Dmitriy Zamarin

Affiliation Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America

Lucy A Perrone

Affiliation Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

Terrence Tumpey

Affiliation Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

Peter Palese

*To whom correspondence should be addressed. E-mail: peter.palese@mssm.edu

Affiliations Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America , Department of Medicine, Mount Sinai School of Medicine, New York, New York, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

All authors conceived and designed the experiments and analyzed the data. GMC, DZ, LAP, and TT performed the experiments. GMC, DZ, TT, and PP wrote the paper.

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Viral pathogens
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Pathogenesis
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Influenza A virus
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Microbial mutation
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Mouse models
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H5N1
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Pandemics
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Cytokines
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