Serum Amyloid P Aids Complement-Mediated Immunity to Streptococcus pneumoniae

Jose Yuste; Marina Botto; Stephen E Bottoms; Jeremy S Brown

doi:10.1371/journal.ppat.0030120

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Open Access

Peer-reviewed

Research Article

Serum Amyloid P Aids Complement-Mediated Immunity to Streptococcus pneumoniae

Jose Yuste,

Affiliation Centre for Respiratory Research, Department of Medicine, Royal Free and University College Medical School, Rayne Institute, London, United Kingdom
⨯
Marina Botto,

Affiliation Molecular Genetics and Rheumatology Section, Faculty of Medicine, Imperial College, London, United Kingdom
⨯
Stephen E Bottoms,

Affiliation Centre for Respiratory Research, Department of Medicine, Royal Free and University College Medical School, Rayne Institute, London, United Kingdom
⨯
Jeremy S Brown

*To whom correspondence should be addressed. E-mail: jeremy.brown@ucl.ac.uk

Affiliation Centre for Respiratory Research, Department of Medicine, Royal Free and University College Medical School, Rayne Institute, London, United Kingdom
⨯

Serum Amyloid P Aids Complement-Mediated Immunity to Streptococcus pneumoniae

Jose Yuste,
Marina Botto,
Stephen E Bottoms,
Jeremy S Brown

Published: September 7, 2007
https://doi.org/10.1371/journal.ppat.0030120

About the Authors

Jose Yuste

Affiliation Centre for Respiratory Research, Department of Medicine, Royal Free and University College Medical School, Rayne Institute, London, United Kingdom

Marina Botto

Affiliation Molecular Genetics and Rheumatology Section, Faculty of Medicine, Imperial College, London, United Kingdom

Stephen E Bottoms

Affiliation Centre for Respiratory Research, Department of Medicine, Royal Free and University College Medical School, Rayne Institute, London, United Kingdom

Jeremy S Brown

*To whom correspondence should be addressed. E-mail: jeremy.brown@ucl.ac.uk

Affiliation Centre for Respiratory Research, Department of Medicine, Royal Free and University College Medical School, Rayne Institute, London, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

JY, MB, and JSB conceived and designed the experiments. JY, SEB, and JSB performed the experiments. JY and JSB analyzed the data and wrote the paper. MB and SEB contributed reagents/materials/analysis tools.

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Pneumococcus
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Mouse models
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Phagocytosis
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Complement system
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Inflammation
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Bacterial pathogens
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Flow cytometry
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Pneumonia
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