EC5S Ubiquitin Complex Is Recruited by KSHV Latent Antigen LANA for Degradation of the VHL and p53 Tumor Suppressors

Qi-Liang Cai; Jason S Knight; Suhbash C Verma; Philip Zald; Erle S Robertson

doi:10.1371/journal.ppat.0020116

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Open Access

Peer-reviewed

Research Article

EC₅S Ubiquitin Complex Is Recruited by KSHV Latent Antigen LANA for Degradation of the VHL and p53 Tumor Suppressors

Qi-Liang Cai,

Affiliation Department of Microbiology and the Tumor Virology Program, Abramson Comprehensive Cancer Center, University of Pennsylvania Medical School, Philadelphia, Pennsylvania, United States of America
⨯
Jason S Knight,

Affiliation Department of Microbiology and the Tumor Virology Program, Abramson Comprehensive Cancer Center, University of Pennsylvania Medical School, Philadelphia, Pennsylvania, United States of America
⨯
Suhbash C Verma,

Affiliation Department of Microbiology and the Tumor Virology Program, Abramson Comprehensive Cancer Center, University of Pennsylvania Medical School, Philadelphia, Pennsylvania, United States of America
⨯
Philip Zald,

Affiliation Department of Microbiology and the Tumor Virology Program, Abramson Comprehensive Cancer Center, University of Pennsylvania Medical School, Philadelphia, Pennsylvania, United States of America
⨯
Erle S Robertson

*To whom correspondence should be addressed. E-mail: erle@mail.med.upenn.edu

Affiliation Department of Microbiology and the Tumor Virology Program, Abramson Comprehensive Cancer Center, University of Pennsylvania Medical School, Philadelphia, Pennsylvania, United States of America
⨯

EC₅S Ubiquitin Complex Is Recruited by KSHV Latent Antigen LANA for Degradation of the VHL and p53 Tumor Suppressors

Qi-Liang Cai,
Jason S Knight,
Suhbash C Verma,
Philip Zald,
Erle S Robertson

Published: October 27, 2006
https://doi.org/10.1371/journal.ppat.0020116

About the Authors

Qi-Liang Cai

Affiliation Department of Microbiology and the Tumor Virology Program, Abramson Comprehensive Cancer Center, University of Pennsylvania Medical School, Philadelphia, Pennsylvania, United States of America

Jason S Knight

Suhbash C Verma

Philip Zald

Erle S Robertson

*To whom correspondence should be addressed. E-mail: erle@mail.med.upenn.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

ESR supervised the overall design and execution of all experiments from initiation to submission of the manuscript. QLC designed and executed the experiments. JSK, SCV, and PZ assisted in performing some of the experiments and analysis of the generated data. ESR and QLC reviewed the analysis of all the data. QLC, JSK, SCV, and PZ contributed reagents/materials/analysis tools. ESR and QLC wrote and submitted the manuscript.

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Cancers and neoplasms
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Sequence motif analysis
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Transfection
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Ubiquitin ligases
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Ligases
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Immunoprecipitation
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Antibodies
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Kaposi's sarcoma-associated herpesvirus
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