Nuclear Retention of Multiply Spliced HIV-1 RNA in Resting CD4+ T Cells

Kara G Lassen; Kasra X Ramyar; Justin R Bailey; Yan Zhou; Robert F Siliciano

doi:10.1371/journal.ppat.0020068

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Open Access

Peer-reviewed

Research Article

Nuclear Retention of Multiply Spliced HIV-1 RNA in Resting CD4⁺ T Cells

Kara G Lassen,

Affiliation Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Kasra X Ramyar,

Affiliation Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Justin R Bailey,

Affiliation Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Yan Zhou,

Affiliation Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Robert F Siliciano

*To whom correspondence should be addressed. E-mail: rsiliciano@jhmi.edu

Affiliations Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America , Howard Hughes Medical Institute, Baltimore, Maryland, United States of America
⨯

Nuclear Retention of Multiply Spliced HIV-1 RNA in Resting CD4⁺ T Cells

Kara G Lassen,
Kasra X Ramyar,
Justin R Bailey,
Yan Zhou,
Robert F Siliciano

Published: July 7, 2006
https://doi.org/10.1371/journal.ppat.0020068

About the Authors

Kara G Lassen

Affiliation Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Kasra X Ramyar

Affiliation Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Justin R Bailey

Affiliation Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Yan Zhou

Affiliation Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Robert F Siliciano

*To whom correspondence should be addressed. E-mail: rsiliciano@jhmi.edu

Affiliations Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America , Howard Hughes Medical Institute, Baltimore, Maryland, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

KGL conceived and designed the experiments. KGL, KXR, and JRB performed the experiments. KGL and RFS analyzed the data. KXR, JRB, and YZ contributed reagents/materials/analysis tools. KGL and RFS wrote the paper.

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HIV-1
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T cells
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Transfection
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Highly-active antiretroviral therapy
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Gene expression
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RNA-binding proteins
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Viral persistence and latency
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Viral replication
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