Effective Control of Chronic γ-Herpesvirus Infection by Unconventional MHC Class Ia–Independent CD8 T Cells

Douglas C Braaten; James Scott McClellan; Ilhem Messaoudi; Scott A Tibbetts; Kelly B McClellan; Janko Nikolich-Zugich; Herbert W Virgin IV

doi:10.1371/journal.ppat.0020037

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Research Article

Effective Control of Chronic γ-Herpesvirus Infection by Unconventional MHC Class Ia–Independent CD8 T Cells

Douglas C Braaten ,

Contributed equally to this work with: Douglas C Braaten, James Scott McClellan, Ilhem Messaoudi, Janko Nikolich-Zugich, Herbert W Virgin IV

Affiliations Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America , Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
James Scott McClellan ,

Contributed equally to this work with: Douglas C Braaten, James Scott McClellan, Ilhem Messaoudi, Janko Nikolich-Zugich, Herbert W Virgin IV

Affiliations Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America , Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Ilhem Messaoudi ,

Contributed equally to this work with: Douglas C Braaten, James Scott McClellan, Ilhem Messaoudi, Janko Nikolich-Zugich, Herbert W Virgin IV

Affiliation Department of Microbiology and Immunology, Oregon Health and Science University, Beaverton, Oregon, United States of America
⨯
Scott A Tibbetts,

Affiliations Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America , Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Kelly B McClellan,

Affiliations Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America , Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Janko Nikolich-Zugich ,

Contributed equally to this work with: Douglas C Braaten, James Scott McClellan, Ilhem Messaoudi, Janko Nikolich-Zugich, Herbert W Virgin IV

Affiliation Department of Microbiology and Immunology, Oregon Health and Science University, Beaverton, Oregon, United States of America
⨯
Herbert W Virgin IV

Contributed equally to this work with: Douglas C Braaten, James Scott McClellan, Ilhem Messaoudi, Janko Nikolich-Zugich, Herbert W Virgin IV

*To whom correspondence should be addressed. E-mail: virgin@wustl.edu

Affiliations Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America , Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯

Effective Control of Chronic γ-Herpesvirus Infection by Unconventional MHC Class Ia–Independent CD8 T Cells

Douglas C Braaten,
James Scott McClellan,
Ilhem Messaoudi,
Scott A Tibbetts,
Kelly B McClellan,
Janko Nikolich-Zugich,
Herbert W Virgin IV

Published: May 19, 2006
https://doi.org/10.1371/journal.ppat.0020037

About the Authors

Douglas C Braaten

Contributed equally to this work with: Douglas C Braaten, James Scott McClellan, Ilhem Messaoudi, Janko Nikolich-Zugich, Herbert W Virgin IV

Affiliations Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America , Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America

James Scott McClellan

Contributed equally to this work with: Douglas C Braaten, James Scott McClellan, Ilhem Messaoudi, Janko Nikolich-Zugich, Herbert W Virgin IV

Ilhem Messaoudi

Contributed equally to this work with: Douglas C Braaten, James Scott McClellan, Ilhem Messaoudi, Janko Nikolich-Zugich, Herbert W Virgin IV

Affiliation Department of Microbiology and Immunology, Oregon Health and Science University, Beaverton, Oregon, United States of America

Scott A Tibbetts

Kelly B McClellan

Janko Nikolich-Zugich

Contributed equally to this work with: Douglas C Braaten, James Scott McClellan, Ilhem Messaoudi, Janko Nikolich-Zugich, Herbert W Virgin IV

Affiliation Department of Microbiology and Immunology, Oregon Health and Science University, Beaverton, Oregon, United States of America

Herbert W Virgin IV

Contributed equally to this work with: Douglas C Braaten, James Scott McClellan, Ilhem Messaoudi, Janko Nikolich-Zugich, Herbert W Virgin IV

*To whom correspondence should be addressed. E-mail: virgin@wustl.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

All the authors conceived and designed the experiments. DCB, JSM, IM, and KBM performed the experiments. All the authors analyzed the data. JNZ and HWV contributed reagents/materials/analysis tools. DCB, JSM, and HWV wrote the paper.

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T cells
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Cytotoxic T cells
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Viral persistence and latency
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Major histocompatibility complex
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Viral transmission and infection
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