Genome-Wide Analysis of Group A Streptococci Reveals a Mutation That Modulates Global Phenotype and Disease Specificity

Paul Sumby; Adeline R Whitney; Edward A Graviss; Frank R DeLeo; James M Musser

doi:10.1371/journal.ppat.0020005

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Peer-reviewed

Research Article

Genome-Wide Analysis of Group A Streptococci Reveals a Mutation That Modulates Global Phenotype and Disease Specificity

Paul Sumby,

Affiliations Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital Research Institute, Houston, Texas, United States of America , Center for Human Bacterial Pathogenesis Research, Department of Pathology, Baylor College of Medicine, Houston, Texas, United States of America
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Adeline R Whitney,

Affiliation Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
⨯
Edward A Graviss,

Affiliation Center for Human Bacterial Pathogenesis Research, Department of Pathology, Baylor College of Medicine, Houston, Texas, United States of America
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Frank R DeLeo,

Affiliation Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
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James M Musser

*To whom correspondence should be addressed. E-mail: jmmusser@tmh.tmc.edu

Affiliations Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital Research Institute, Houston, Texas, United States of America , Center for Human Bacterial Pathogenesis Research, Department of Pathology, Baylor College of Medicine, Houston, Texas, United States of America
⨯

Genome-Wide Analysis of Group A Streptococci Reveals a Mutation That Modulates Global Phenotype and Disease Specificity

Paul Sumby,
Adeline R Whitney,
Edward A Graviss,
Frank R DeLeo,
James M Musser

Published: January 27, 2006
https://doi.org/10.1371/journal.ppat.0020005

About the Authors

Paul Sumby

Affiliations Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital Research Institute, Houston, Texas, United States of America , Center for Human Bacterial Pathogenesis Research, Department of Pathology, Baylor College of Medicine, Houston, Texas, United States of America

Adeline R Whitney

Affiliation Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America

Edward A Graviss

Affiliation Center for Human Bacterial Pathogenesis Research, Department of Pathology, Baylor College of Medicine, Houston, Texas, United States of America

Frank R DeLeo

James M Musser

*To whom correspondence should be addressed. E-mail: jmmusser@tmh.tmc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

PS, FRD, and JMM conceived and designed the experiments. PS and ARW performed the experiments. PS, ARW, EAG, FRD, and JMM analyzed the data. PS and JMM wrote the paper.

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Transcriptome analysis
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Virulence factors
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Mammalian genomics
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Mouse models
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Bacterial pathogens
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Gene expression
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Lesions
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Microarrays
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