A Novel Endogenous Inhibitor of the Secreted Streptococcal NAD-Glycohydrolase

Michael A Meehl; Jerome S Pinkner; Patricia J Anderson; Scott J Hultgren; Michael G Caparon

doi:10.1371/journal.ppat.0010035

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Open Access

Peer-reviewed

Research Article

A Novel Endogenous Inhibitor of the Secreted Streptococcal NAD-Glycohydrolase

Michael A Meehl,

Affiliation Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Jerome S Pinkner,

Affiliation Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Patricia J Anderson,

Affiliations Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Scott J Hultgren,

Affiliation Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Michael G Caparon

*To whom correspondence should be addressed. E-mail: caparon@borcim.wustl.edu

Affiliation Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯

A Novel Endogenous Inhibitor of the Secreted Streptococcal NAD-Glycohydrolase

Michael A Meehl,
Jerome S Pinkner,
Patricia J Anderson,
Scott J Hultgren,
Michael G Caparon

Published: December 2, 2005
https://doi.org/10.1371/journal.ppat.0010035

About the Authors

Michael A Meehl

Affiliation Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America

Jerome S Pinkner

Affiliation Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America

Patricia J Anderson

Affiliations Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America

Scott J Hultgren

Affiliation Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America

Michael G Caparon

*To whom correspondence should be addressed. E-mail: caparon@borcim.wustl.edu

Affiliation Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

MAM, JSP, PJA, and MGC conceived and designed the experiments. MAM and JSP performed the experiments. MAM, JSP, PJA, and MGC analyzed the data. PJA, SJH, and MGC contributed reagents/materials/analysis tools. MAM, PJA, and MGC wrote the paper.

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Streptococcus pyogenes
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Bacterial pathogens
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Protein extraction
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Toxins
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Plasmid construction
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Streptococcus
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Host cells
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Pathogenesis
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