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Tyrosine kinases

Mechanistic evaluation of NSC 57774 as a SHP2 inhibitor in gastric cancer: Multi-pathway signaling modulation in vitro

Ghalia Khoder, Rose Ghemrawi, Nour Sammani, Rania Harati, Mohamad Hamad, Jibran Sualeh Muhammad, Walaa Mousa, Mostafa Khair

published 30 Jul 2026

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HIV-1 Nef inhibits the JAK/STAT signaling pathway by inducing proteasomal degradation of STAT1

Roger L. Rodrigues, Mara E. da Silva-Januário, Vinicius B. Apolloni, Constanza E. Espada, Taissa R. Jorge, Lucas A. Tavares, Andreia N. de Carvalho, Juliano P. Souza, Eurico Arruda, Iranaia Assunção-Miranda, Daniel S. Mansur, Luis L. P. daSilva

published 10 Jul 2026

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Higher frequency of subclonal anti-EGFR resistance mutations in post-treatment samples from patients with colorectal cancer liver metastases following anti-EGFR-based conversion chemotherapy

Christoph Steup, Antonia Mondorf, Peter Wild, Ursula Pession, Wolf Otto Bechstein, Florian A. Michael, Melanie Winter, Julia Bein, Stefan Zeuzem, Jörg Trojan, Christine Koch

published 06 Jul 2026

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Inhibition of purine nucleoside and nucleobase transporters by tyrosine kinase inhibitors

Nayiar Shahid, Chan H. Kim, Kerrylei B. Jabilona, Khanh H. Nguyen, Nicholas M. Ruel, James R. Hammond

published 15 May 2026

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Characterization of the TREM-1 signaling landscape in human neutrophils

Frederic Ries, Matthias Klein, Nora Rogmann, Sophie Többen, Federico Marini, Florian Heidel, Markus P. Radsak

published 05 Mar 2026

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Genome-wide association study revealed genomic regions associated with tuber quality traits in water yam (Dioscorea alata L.)

Fatoumata Ouattara, Paterne A. Agre, Idris I. Adejumobi, Bunmi Olasanmi, Adekemi Stanley, Fatogoma Sorho, Konan E. B. Dibi, Malachy O. Akoroda, Ranjana Bhattacharjee

published 04 Feb 2026

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Integrated analysis of ARHGAP6 potential function and prognostic value in acute myeloid leukemia

Debin Yang, Yuanzhe Li, Ping Ma, Fankai Xiao

published 07 Oct 2025

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Next-Generation Sequencing (NGS) in non-small cell lung carcinoma: A real-world experience in the public health system of Galicia (Northwest Spain)

Ihab Abdulkader-Nallib, José Manuel Cameselle-Teijeiro, Iván Lesende-Rodríguez, Raquel Pérez-Becerra, José Ramón Antúnez-López, Jorge García-González, Luis León-Mateos, María Sánchez-Ares

published 01 Jul 2025

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Functional kinome profiling reveals brain protein kinase signaling pathways and gene networks altered by acute voluntary exercise in rats

Chia-Ming Lee, Jennifer Nguyen, Brock Pope, Ali Sajid Imami, V. William George Ryan, Smita Sahay, Victoria Mathis, Priyanka Pulvender, Hunter Michael Eby, Taylen Arvay, Khaled Alganem, Lauren Wegman-Points, Robert McCullunsmith, Li-Lian Yuan

published 15 Apr 2025

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Development and comparison of single FLT3-inhibitors to dual FLT3/TAF1-inhibitors as an anti-leukemic approach

Robert S. Leigh, Bogac L. Kaynak, Heikki Ruskoaho, Mika J. Välimäki

published 28 Mar 2025

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Exploratory study of serum protein biomarkers for sudden cardiac arrest using protein extension assay: A case-control study

Ha Yeon Shin, Jeong Ho Park, Kyoung-Chul Cha, Hyun Je Kim, Woo Jin Jung, Seulki Choi, Ji Hwan Moon, Young Il Roh, Young Sun Ro, Sung Oh Hwang, Sang Do Shin, for CAPTURES-II Investigators

published 24 Feb 2025

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Complex regulation of Ca_v2.2 N-type Ca²⁺ channels by Ca²⁺ and G-proteins

Jessica R. Thomas, Jinglang Sun, Juan De la Rosa Vazquez, Amy Lee

published 07 Feb 2025

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Comparison of actionable alterations in cancers with kinase fusion, mutation, and copy number alteration

Shinsuke Suzuki, Toshiaki Akahane, Akihide Tanimoto, Michiyo Higashi, Ikumi Kitazono, Mari Kirishima, Masakazu Nishigaki, Toshiro Ikeda, Shuichi Kanemitsu, Junichi Nakazawa, Erina Akahane, Hiroshi Nishihara, Kimiharu Uozumi, Makoto Yoshimitsu, Kenji Ishitsuka, Shin-ichi Ueno

published 23 Jan 2025

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