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STAT signaling

Dapagliflozin mitigates myocardial inflammation and metabolic stress in heart failure through STAT1 inhibition: Evidence from multi-omics analyses and experimental exploration

Lianqi He, Di Zhang, Shiwen Zhang, Zhichao Ren, Yihong Huangfu, Xiran Cheng, Zhanchun Song

published 27 Feb 2026

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The JAK1-STAT1 signaling pathway triggers inflammation responses in chronic obstructive sleep apnea rat model

Lin Yang, Jie He

published 17 Feb 2026

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Blockade of interleukin-6 (IL-6) signaling in dedifferentiated liposarcoma (DDLPS) decreases mouse double minute 2 (MDM2) oncogenicity via alternative splicing

Abeba Zewdu, Danielle Braggio, Gonzalo Lopez, Kara Batte, Safiya Khurshid, Fernanda Costas C. de Faria, Hemant K. Bid, David Koller, Lucia Casadei, Katherine J. Ladner, David Wang, Valerie Grignol, O. Hans Iwenofu, Dawn Chandler, Denis C. Guttridge, Raphael E. Pollock

published 17 Sep 2025

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JAK inhibitor withdrawal causes a transient pro-inflammatory cascade: A potential mechanism for major adverse cardiac events

Ilya Gurevic, Loic Meudec, Xavier Mariette, Gaetane Nocturne, Sara S. McCoy

published 16 Jun 2025

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The effect of lidocaine against sepsis-induced acute lung injury in a mouse model through the JAK2/STAT3 pathway

Ying Cai, Hong Zhang, Lun-Meng Cui, Qian Chen, Feng-Jie Xie

published 08 May 2025

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The ubiquitin-like modifier FAT10 does not affect IL-12 expression and signaling

Jinjing Cao, Gerardo Omar Alvarez Salinas, Gunter Schmidtke, Michael Basler

published 06 May 2025

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Delayed hepatic response and impaired cytokine dynamics in aged mice following burn injury: Implications for elderly patient care

Israel Muro, Andrea C. Qualman, Kenneth Meza Monge, Akshay Pratap, Elizabeth J. Kovacs, Juan-Pablo Idrovo

published 24 Feb 2025

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NOTCH1 promotes the elevation of GM-CSF and IL-6 through the EZH2/STAT3 pathway to facilitate the fibrotic state of the myocardium in DLBCL

Huimin Zhang, Wen Dong, Lihong Zhang, Bing Ma, Jianying Wang, Yang Shen, Dan Zhao, Wanyi Yin, Yuexian Li, Qingchi Liu

published 14 Feb 2025

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Exploration and verification of the therapeutic mechanism of shenfu injection in sepsis-induced myocardial injury

Hua-jing Yuan, Guo-han Xiang, Yang Liu, Yan Li, Wen-li Liu, Jiu-xiang Wei, Yi-tao Xue, Hao Hao

published 17 Jan 2025

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Hypomethylation of IL6ST promotes development of endometriosis by activating JAK2/STAT3 signaling pathway

Yue Hu, Hailong Chen, Lijuan Jin, Xiumei Chi, Jian Zhao, Qinying Cao

published 16 Jan 2025

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Microbiota-derived proteins synergize with IL-23 to drive IL22 production in model type 3 innate lymphoid cells

Yanling Wang, David S. J. Allan, Andrew T. Gewirtz

published 13 Jan 2025

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Loss of STAT3 in osteoblasts has detrimental and sexually dimorphic effects on skeletal development

Rebecca K. Davidson, Kylie Corry, Amos Orlofsky, Ping Li, Caleb E. Russell, Amy Zhang, Mariana Moraes de Lima Perini, Carlie N. Priddy, Andrew V. Nguyen, Jiliang Li

published 17 Dec 2024

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Maggot extract accelerates skin wound healing of diabetic rats via enhancing STAT3 signaling

Mo-Li Wu, Zhe-Ming Yang, Hai-Chao Dong, Hong Zhang, Xu Zheng, Bo Yuan, Yang Yang, Jia Liu, Pei-Nan Li

published 06 Sep 2024

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