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Small molecules

Non-invasive phenotyping and drug testing in single cardiomyocytes or beta-cells by calcium imaging and optogenetics

Yu-Fen Chang, Connor N. Broyles, [ ... ], Matthew J. Daniels

Global Analysis Reveals Families of Chemical Motifs Enriched for hERG Inhibitors

Fang Du, Joseph J. Babcock, [ ... ], Min Li

Characterization of Pellicle Inhibition in Gluconacetobacter xylinus 53582 by a Small Molecule, Pellicin, Identified by a Chemical Genetics Screen

Janice L. Strap, Andrew Latos, Isaac Shim, Dario T. Bonetta

A High-Throughput Assay for Small Molecule Destabilizers of the KRAS Oncoprotein

Joseph Carver, Thomas S. Dexheimer, [ ... ], Ji Luo

Utilization of peptide phage display to investigate hotspots on IL-17A and what it means for drug discovery

Joey P. Ting, Frances Tung, [ ... ], Sepideh Afshar

A Novel CMKLR1 Small Molecule Antagonist Suppresses CNS Autoimmune Inflammatory Disease

Kareem L. Graham, Jian V. Zhang, [ ... ], Brian A. Zabel

Selection of a Novel Anti-Nicotine Vaccine: Influence of Antigen Design on Antibody Function in Mice

David C. Pryde, Lyn H. Jones, [ ... ], Michael J. McCluskie

High-Throughput Screening (HTS) and Hit Validation to Identify Small Molecule Inhibitors with Activity against NS3/4A proteases from Multiple Hepatitis C Virus Genotypes

Hyun Lee, Tian Zhu, [ ... ], Michael E. Johnson

Reprogramming of Various Cell Types to a Beta-Like State by Pdx1, Ngn3 and MafA

Ersin Akinci, Anannya Banga, [ ... ], Jonathan M. W. Slack

Identification of Small-Molecule Inhibitors of Yersinia pestis Type III Secretion System YscN ATPase

Wieslaw Swietnicki, Daniel Carmany, [ ... ], Mark A. Olson

PCC0208025 (BMS202), a small molecule inhibitor of PD-L1, produces an antitumor effect in B16-F10 melanoma-bearing mice

Zhengping Hu, Pengfei Yu, [ ... ], Jingwei Tian

Large-Scale Functional Purification of Recombinant HIV-1 Capsid

Magdeleine Hung, Anita Niedziela-Majka, [ ... ], Roman Sakowicz

Comprehensive Structural and Substrate Specificity Classification of the Saccharomyces cerevisiae Methyltransferome

Tomasz Wlodarski, Jan Kutner, [ ... ], Krzysztof Ginalski

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