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Small molecules

GATA4-targeted compounds induce apoptosis and diminish viability of hepatoblastoma cells

Sini M. Kinnunen, Katja Eloranta, [ ... ], Markku Heikinheimo

Safety population size and duration of exposure prior to approval of new medicines: A database analysis of medicines centralised approved in the European Union between 2011 and 2023

Luísa Bouwman, Hubert Leufkens, Bruno Sepodes, Carla Torre

Clinical proof of concept for small molecule mediated inhibition of IL-17 in psoriasis

Richard B. Warren, Hamish J. A. Hunter, [ ... ], Timothy T. Lu

Phenotypic profiling of small molecules using cell painting assay in HCT116 colorectal cancer cells

Velemir Lavrinenko, Ilona Donskaya, [ ... ], Stanislav Tyazhelnikov

Long-term functional rescue of trauma-induced vision loss by a novel, small molecule TrkB modulator

Shweta Modgil, Christopher L. Walker, [ ... ], P. Michael Iuvone

Understanding the evolving treatment landscape of hidradenitis suppurativa: An analysis of All of Us

Aditya K. Gupta, Vasiliki Economopoulos, Paradi Mirmirani, Renata Magalhaes

Study on the releasing regularity of asphalt fume and its suppression technology

Guang Yang, Yongli Xu, Xiaolei Jiao, Yiming Li

Mechanistic studies of PFKFB2 reveal a novel inhibitor of its kinase activity

Craig Eyster, Satoshi Matsuzaki, [ ... ], Kenneth M. Humphries

In silico analysis to explore the therapeutic potential of propolis-derived small molecules as matriptase inhibitors to suppress breast cancer growth and metastasis

Muhammad Bilal Azmi, Han Yu, [ ... ], Mohnad Abdalla

Virtual screening and molecular dynamics simulation study of ATP-competitive inhibitors targeting mTOR protein

Mei-Yu Jin, Hao Yu, [ ... ], Hui Liang

Identification of potential riboswitch elements in Homo sapiens mRNA 5’UTR sequences using positive-unlabeled machine learning

William S Raymond, Jacob DeRoo, Brian Munsky

Mechanism of connexin channel inhibition by mefloquine and 2-aminoethoxydiphenyl borate

Pia Lavriha, Yufei Han, [ ... ], Volodymyr M. Korkhov

Development of a sequential laser microdissection tissue cuts workflow for the spatial and quantitative analysis of drugs in fresh frozen tissue sections

Elias Maris, Farid Jahouh, Kathleen Allaerts, Rob Vreeken

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