Advertisement

Browse Subject Areas

?

Click through the PLOS taxonomy to find articles in your field.

For more information about PLOS Subject Areas, click here.

Small molecules

Sustained intestinal epithelial monolayer wound closure after transient application of a FAK-activating small molecule

Sema Oncel, Qinggang Wang, Ahmed Adham R. Elsayed, Emilie E. Vomhof-DeKrey, Nicholas D. Brown, Mikhail Y. Golovko, Svetlana A. Golovko, Ricardo Gallardo-Macias, Vadim J. Gurvich, Marc D. Basson

published 16 Aug 2024

Loading metrics information...

Metrics unavailable. Please check back later.

Discovery of a potent, selective, and tumor-suppressing antibody antagonist of adenosine A_2A receptor

Linya Wang, Pankaj Garg, Kara Y. Chan, Tom Z. Yuan, Ana G. Lujan Hernandez, Zhen Han, Sean M. Peterson, Emily Tuscano, Crystal Safavi, Eric Kwan, Mouna Villalta, Melina Mathur, Joyce Lai, Fumiko Axelrod, Colby A. Souders, Chloe Emery, Aaron K. Sato

published 05 Jun 2024

Loading metrics information...

Metrics unavailable. Please check back later.

Discovery of allosteric regulators with clinical potential to stabilize alpha-L-iduronidase in mucopolysaccharidosis type I

Elena Cubero, Ana Ruano, Aida Delgado, Xavier Barril, Sara Morales, Ana Trapero, Lorenzo Leoni, Manolo Bellotto, Roberto Maj, Beatriz Calvo-Flores Guzmán, Natalia Pérez-Carmona, Ana Maria Garcia-Collazo

published 20 May 2024

Loading metrics information...

Metrics unavailable. Please check back later.

Gaussian accelerated molecular dynamics simulations facilitate prediction of the permeability of cyclic peptides

Nicolas Frazee, Kyle R. Billlings, Blake Mertz

published 23 Apr 2024

Loading metrics information...

Metrics unavailable. Please check back later.

An immunochromatographic strip sensor for marbofloxacin residues

Xingdong Yang, Qingmei Li, Sharon Kwee, Jifei Yang, Qianqian Zhang, Xiaofei Hu

published 29 Mar 2024

Loading metrics information...

Metrics unavailable. Please check back later.

Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM

Frances M. Bashore, Vittorio L. Katis, Yuhong Du, Arunima Sikdar, Dongxue Wang, William J. Bradshaw, Karolina A. Rygiel, Tina M. Leisner, Rod Chalk, Swati Mishra, C. Andrew Williams, Opher Gileadi, Paul E. Brennan, Jesse C. Wiley, Jake Gockley, Gregory A. Cary, Gregory W. Carter, Jessica E. Young, Kenneth H. Pearce, Haian Fu, the Emory-Sage-SGC TREAT-AD Center , Alison D. Axtman

published 15 Feb 2024

Loading metrics information...

Metrics unavailable. Please check back later.

Exploring NCATS in-house biomedical data for evidence-based drug repurposing

Fang Liu, Andrew Patt, Chloe Chen, Ruili Huang, Yanji Xu, Ewy A. Mathé, Qian Zhu

published 25 Jan 2024

Loading metrics information...

Metrics unavailable. Please check back later.

Side-by-side comparison of published small molecule inhibitors against thapsigargin-induced store-operated Ca²⁺ entry in HEK293 cells

Katherine Norman, Karen E. Hemmings, Heba Shawer, Hollie L. Appleby, Alan J. Burnett, Nurasyikin Hamzah, Rajendra Gosain, Emily M. Woodhouse, David J. Beech, Richard Foster, Marc A. Bailey

published 23 Jan 2024

Loading metrics information...

Metrics unavailable. Please check back later.

Comprehensive metabolomics of Philippine Stichopus cf. horrens reveals diverse classes of valuable small molecules for biomedical applications

Vicenzo Paolo M. Torreno, Ralph John Emerson J. Molino, Hiyas A. Junio, Eizadora T. Yu

published 06 Dec 2023

Loading metrics information...

Metrics unavailable. Please check back later.

Small molecule inhibitor of tau self-association in a mouse model of tauopathy: A preventive study in P301L tau JNPL3 mice

Eliot J. Davidowitz, Patricia Lopez, Heidy Jimenez, Leslie Adrien, Peter Davies, James G. Moe

published 09 Aug 2023

Loading metrics information...

Metrics unavailable. Please check back later.

High-throughput screening identifies cell cycle-associated signaling cascades that regulate a multienzyme glucosome assembly in human cells

Danielle L. Schmitt, Patricia Dranchak, Prakash Parajuli, Dvir Blivis, Ty Voss, Casey L. Kohnhorst, Minjoung Kyoung, James Inglese, Songon An

published 04 Aug 2023

Loading metrics information...

Metrics unavailable. Please check back later.

How important are concurrent vehicle control groups in (sub)chronic non-human primate toxicity studies conducted in pharmaceutical development? An opportunity to reduce animal numbers

Lars Mecklenburg, Sarah Lenz, Georg Hempel

published 03 Aug 2023

Loading metrics information...

Metrics unavailable. Please check back later.

CCX559 is a potent, orally-administered small molecule PD-L1 inhibitor that induces anti-tumor immunity

Kathleen M. C. Sullivan, Marta Vilalta, Linda S. Ertl, Yu Wang, Carolyn Dunlap, Karen Ebsworth, Bin N. Zhao, Shijie Li, Yibin Zeng, Zhenhua Miao, Pingchen Fan, Venkat Mali, Christopher Lange, Darren McMurtrie, Ju Yang, Rebecca Lui, Ryan Scamp, Vicky Chhina, Alice Kumamoto, Simon Yau, Ton Dang, Ashton Easterday, Shirley Liu, Shichang Miao, Israel Charo, Thomas J. Schall, Penglie Zhang

published 07 Jun 2023

Loading metrics information...

Metrics unavailable. Please check back later.

Advertisement

Create a weekly email alert for: Small molecules

You can change these options by clicking profile then "Alerts and Notifications"