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Site-directed mutagenesis

Enhanced cadmium binding ability in response to novel modifications in a Paramecium cadmium metallothionein PMCd1

Hira Nizam, Asmara Imtiaz, Fareeda Tasneem, Farah Rauf Shakoori, Soumble Zulfiqar, Amina Younas, Sidra Mustafa, Asra Ghaus, Ayesha Zafar, Arshia Nazir, Muhammad Sajjad, Abdul Rauf Shakoori

published 22 May 2025

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Larger active site in an ancestral hydroxynitrile lyase increases catalytically promiscuous esterase activity

Bryan J. Jones, Robert L. Evans III, Nathan J. Mylrea, Debayan Chaudhury, Christine Luo, Bo Guan, Colin T. Pierce, Wendy R. Gordon, Carrie M. Wilmot, Romas J. Kazlauskas

published 30 Jun 2020

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Exploring the molecular structures that confer ligand selectivity for galanin type II and III receptors

Yoo-Na Lee, Arfaxad Reyes-Alcaraz, Seongsik Yun, Cheol Soon Lee, Jong-Ik Hwang, Jae Young Seong

published 31 Mar 2020

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Transcriptional regulation of the Pseudomonas aeruginosa iron-sulfur cluster assembly pathway by binding of IscR to multiple sites

Kritsakorn Saninjuk, Adisak Romsang, Jintana Duang-nkern, Paiboon Vattanaviboon, Skorn Mongkolsuk

published 28 Jun 2019

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Peak emission wavelength and fluorescence lifetime are coupled in far-red, GFP-like fluorescent proteins

Laura Canty, Santosh Hariharan, Qian Liu, Steven A. Haney, David W. Andrews

published 28 Nov 2018

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Molecular basis of inhibition of acid sensing ion channel 1A by diminazene

Aram J. Krauson, James G. Rooney, Marcelo D. Carattino

published 21 May 2018

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Generation of efficient mutants of endoglycosidase from Streptococcus pyogenes and their application in a novel one-pot transglycosylation reaction for antibody modification

Mitsuhiro Iwamoto, Yukiko Sekiguchi, Kensuke Nakamura, Yoshirou Kawaguchi, Takeshi Honda, Jun Hasegawa

published 23 Feb 2018

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Three unrelated and unexpected amino acids determine the susceptibility of the interface cysteine to a sulfhydryl reagent in the triosephosphate isomerases of two trypanosomes

Selma Díaz-Mazariegos, Nallely Cabrera, Ruy Perez-Montfort

published 17 Jan 2018

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An L213A variant of β-glycosidase from Sulfolobus solfataricus with increased α-L-arabinofuranosidase activity converts ginsenoside Rc to compound K

Ji-Hyeon Choi, Kyung-Chul Shin, Deok-Kun Oh

published 11 Jan 2018

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Exploring the role of L209 residue in the active site of NDM-1 a metallo-β-lactamase

Francesca Marcoccia, Hanna-Kirsti S. Leiros, Massimiliano Aschi, Gianfranco Amicosante, Mariagrazia Perilli

published 02 Jan 2018

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Evolution-guided adaptation of an adenylation domain substrate specificity to an unusual amino acid

Simon Vobruba, Stanislav Kadlcik, Radek Gazak, Jiri Janata

published 14 Dec 2017

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Engineering substrate promiscuity in halophilic alcohol dehydrogenase (HvADH2) by in silico design

Jennifer Cassidy, Larah Bruen, Elena Rosini, Gianluca Molla, Loredano Pollegioni, Francesca Paradisi

published 30 Nov 2017

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Involvement of arginine 878 together with Ca²⁺ in mouse aminopeptidase A substrate specificity for N-terminal acidic amino-acid residues

Pierre Couvineau, Hugo de Almeida, Bernard Maigret, Catherine Llorens-Cortes, Xavier Iturrioz

published 06 Sep 2017

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