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SH2 domains

SRC-1 controls growth cone polarity and protrusion with the UNC-6/Netrin receptor UNC-5 in Caenorhabditis elegans

Snehal S. Mahadik, Emily K. Burt, Erik A. Lundquist

published 21 May 2024

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Role of two modules controlling the interaction between SKAP1 and SRC kinases comparison with SKAP2 architecture and consequences for evolution

Laurine Levillayer, Camille Brighelli, Caroline Demeret, Anavaj Sakuntabhai, Jean-François Bureau

published 14 Mar 2024

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SHP-1 tyrosine phosphatase binding to c-Src kinase phosphor-dependent conformations: A comparative structural framework

Mehreen Gul, Ahmad Navid, Muhammad Fakhar, Sajid Rashid

published 13 Jan 2023

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High prevalence of low-allele-fraction somatic mutations in STAT3 in peripheral blood CD8+ cells in multiple sclerosis patients and controls

Miko Valori, Joonas Lehikoinen, Lilja Jansson, Jonna Clancy, Sofie A. Lundgren, Satu Mustjoki, Pentti Tienari

published 28 Nov 2022

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The SH2 domain and kinase activity of JAK2 target JAK2 to centrosome and regulate cell growth and centrosome amplification

Aashirwad Shahi, Jacob Kahle, Chandler Hopkins, Maria Diakonova

published 28 Jan 2022

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NHD2-15, a novel antagonist of Growth Factor Receptor-Bound Protein-2 (GRB2), inhibits leukemic proliferation

Tina R. Lewis, Jesse Smith, Kallie Griffin, Stephanie Aguiar, Kristen F. Rueb, Natalie Holmberg-Douglas, Ellen M. Sampson, Skylar Tomasetti, Sofia Rodriguez, David L. Stachura, Carolynn C. Arpin

published 11 Aug 2020

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Crystal structures of p120RasGAP N-terminal SH2 domain in its apo form and in complex with a p190RhoGAP phosphotyrosine peptide

Rachel Jaber Chehayeb, Amy L. Stiegler, Titus J. Boggon

published 31 Dec 2019

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Identification of novel small molecules that inhibit STAT3-dependent transcription and function

Iryna Kolosenko, Yasmin Yu, Sander Busker, Matheus Dyczynski, Jianping Liu, Martin Haraldsson, Caroline Palm Apergi, Thomas Helleday, Katja Pokrovskaja Tamm, Brent D. G. Page, Dan Grander

published 21 Jun 2017

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Inhibition of STAT3 by Anticancer Drug Bendamustine

Kazunori Iwamoto, Yutaka Uehara, Yukie Inoue, Kyoko Taguchi, Daisuke Muraoka, Naohisa Ogo, Kenji Matsuno, Akira Asai

published 26 Jan 2017

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SmShb, the SH2-Containing Adaptor Protein B of Schistosoma mansoni Regulates Venus Kinase Receptor Signaling Pathways

Marion Morel, Mathieu Vanderstraete, Katia Cailliau, Steffen Hahnel, Christoph G. Grevelding, Colette Dissous

published 16 Sep 2016

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Crystal Structure of the FERM-SH2 Module of Human Jak2

Randall McNally, Angela V. Toms, Michael J. Eck

published 26 May 2016

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Tyrosine Phosphorylation of Caspase-8 Abrogates Its Apoptotic Activity and Promotes Activation of c-Src

Jennifer LY Tsang, Song Hui Jia, Jean Parodo, Pamela Plant, Monika Lodyga, Emmanuel Charbonney, Katalin Szaszi, Andras Kapus, John C. Marshall

published 21 Apr 2016

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A Central Nervous System-Dependent Intron-Embedded Gene Encodes a Novel Murine Fyn Binding Protein

Noureddine Ben Khalaf, Safa Taha, Moiz Bakhiet, M. Dahmani Fathallah

published 22 Feb 2016

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