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Pyrimethamine

Repurposing the Medicines for Malaria Venture’s COVID Box to discover potent inhibitors of Toxoplasma gondii, and in vivo efficacy evaluation of almitrine bismesylate (MMV1804175) in chronically infected mice

Bruna Ramos dos Santos, Amanda Bruno da Silva Bellini Ramos, Renata Priscila Barros de Menezes, Marcus Tullius Scotti, Fábio Antônio Colombo, Marcos José Marques, Juliana Quero Reimão

published 07 Jul 2023

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Knockout of Babesia bovis rad51 ortholog and its complementation by expression from the BbACc3 artificial chromosome platform

Erin A. Mack, Yu-Ping Xiao, David R. Allred

published 06 Aug 2019

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High-content imaging assay to evaluate Toxoplasma gondii infection and proliferation: A multiparametric assay to screen new compounds

Bastien Touquet, Léonie Pelissier, Pierre Cavailles, Wei Yi, Valeria Bellini, Corinne Mercier, Marie-France Cesbron-Delauw, Ahcène Boumendjel, Delphine Aldebert

published 29 Aug 2018

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Expression, purification, and inhibition profile of dihydrofolate reductase from the filarial nematode Wuchereria bancrofti

Andrew M. Tobias, Dea Toska, Keith Lange, Tyler Eck, Rohit Bhat, Cheryl A. Janson, David P. Rotella, Ueli Gubler, Nina M. Goodey

published 22 May 2018

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Identification of compounds that suppress Toxoplasma gondii tachyzoites and bradyzoites

Yuho Murata, Tatsuki Sugi, Louis M. Weiss, Kentaro Kato

published 13 Jun 2017

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Seasonal Malaria Chemoprevention with Sulphadoxine-Pyrimethamine and Amodiaquine Selects Pfdhfr-dhps Quintuple Mutant Genotype in Mali

Hamma Maiga, Estrella Lasry, Modibo Diarra, Issaka Sagara, Amadou Bamadio, Aliou Traore, Samba Coumare, Soma Bahonan, Boubou Sangare, Yeyia Dicko, Nouhoum Diallo, Aly Tembely, Djibril Traore, Hamidou Niangaly, François Dao, Aboubecrine Haidara, Alassane Dicko, Ogobara K. Doumbo, Abdoulaye A. Djimde

published 23 Sep 2016

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Dihydrofolate-Reductase Mutations in Plasmodium knowlesi Appear Unrelated to Selective Drug Pressure from Putative Human-To-Human Transmission in Sabah, Malaysia

Matthew J. Grigg, Bridget E. Barber, Jutta Marfurt, Mallika Imwong, Timothy William, Elspeth Bird, Kim A. Piera, Ammar Aziz, Usa Boonyuen, Christopher J. Drakeley, Jonathan Cox, Nicholas J. White, Qin Cheng, Tsin W. Yeo, Sarah Auburn, Nicholas M. Anstey

published 01 Mar 2016

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Glucose-6-Phosphate Dehydrogenase Deficiency and Haemoglobin Drop after Sulphadoxine-Pyrimethamine Use for Intermittent Preventive Treatment of Malaria during Pregnancy in Ghana – A Cohort Study

Ruth Owusu, Kwaku Poku Asante, Emmanuel Mahama, Elizabeth Awini, Thomas Anyorigiya, David Dosoo, Alberta Amu, Gabriel Jakpa, Emmanuel Ofei, Sylvester Segbaya, Abraham Rexford Oduro, Margaret Gyapong, Abraham Hodgson, Constance Bart-Plange, Seth Owusu-Agyei

published 01 Sep 2015

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Transport Mechanisms and Their Pathology-Induced Regulation Govern Tyrosine Kinase Inhibitor Delivery in Rheumatoid Arthritis

Christian Schmidt-Lauber, Saliha Harrach, Thomas Pap, Meike Fischer, Marion Victor, Marianne Heitzmann, Uwe Hansen, Manfred Fobker, Stefan-Martin Brand, Aleksandra Sindic, Hermann Pavenstädt, Bayram Edemir, Eberhard Schlatter, Jessica Bertrand, Giuliano Ciarimboli

published 20 Dec 2012

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Functional Analysis of Plasmodium vivax Dihydrofolate Reductase-Thymidylate Synthase Genes through Stable Transformation of Plasmodium falciparum

Alyson M. Auliff, Bharath Balu, Nanhua Chen, Michael T. O’Neil, Qin Cheng, John H. Adams

published 09 Jul 2012

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Fitness Trade-Offs in the Evolution of Dihydrofolate Reductase and Drug Resistance in Plasmodium falciparum

Marna S. Costanzo, Kyle M. Brown, Daniel L. Hartl

published 23 May 2011

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Towards an In Vitro Model of Plasmodium Hypnozoites Suitable for Drug Discovery

Laurent Dembele, Audrey Gego, Anne-Marie Zeeman, Jean-François Franetich, Olivier Silvie, Armelle Rametti, Roger Le Grand, Nathalie Dereuddre-Bosquet, Robert Sauerwein, Geert-Jan van Gemert, Jean-Christophe Vaillant, Alan W. Thomas, Georges Snounou, Clemens H. M. Kocken, Dominique Mazier

published 31 Mar 2011

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Effects of Point Mutations in Plasmodium falciparum Dihydrofolate Reductase and Dihydropterate Synthase Genes on Clinical Outcomes and In Vitro Susceptibility to Sulfadoxine and Pyrimethamine

David J. Bacon, Doug Tang, Carola Salas, Norma Roncal, Carmen Lucas, Lucia Gerena, Lorena Tapia, A. Alejandro Llanos-Cuentas, Coralith Garcia, Lelv Solari, Dennis Kyle, Alan J. Magill

published 26 Aug 2009

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