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Pyrimethamine

Repurposing the Medicines for Malaria Venture’s COVID Box to discover potent inhibitors of Toxoplasma gondii, and in vivo efficacy evaluation of almitrine bismesylate (MMV1804175) in chronically infected mice

Bruna Ramos dos Santos, Amanda Bruno da Silva Bellini Ramos, [ ... ], Juliana Quero Reimão

Knockout of Babesia bovis rad51 ortholog and its complementation by expression from the BbACc3 artificial chromosome platform

Erin A. Mack, Yu-Ping Xiao, David R. Allred

High-content imaging assay to evaluate Toxoplasma gondii infection and proliferation: A multiparametric assay to screen new compounds

Bastien Touquet, Léonie Pelissier, [ ... ], Delphine Aldebert

Expression, purification, and inhibition profile of dihydrofolate reductase from the filarial nematode Wuchereria bancrofti

Andrew M. Tobias, Dea Toska, [ ... ], Nina M. Goodey

Identification of compounds that suppress Toxoplasma gondii tachyzoites and bradyzoites

Yuho Murata, Tatsuki Sugi, Louis M. Weiss, Kentaro Kato

Seasonal Malaria Chemoprevention with Sulphadoxine-Pyrimethamine and Amodiaquine Selects Pfdhfr-dhps Quintuple Mutant Genotype in Mali

Hamma Maiga, Estrella Lasry, [ ... ], Abdoulaye A. Djimde

Dihydrofolate-Reductase Mutations in Plasmodium knowlesi Appear Unrelated to Selective Drug Pressure from Putative Human-To-Human Transmission in Sabah, Malaysia

Matthew J. Grigg, Bridget E. Barber, [ ... ], Nicholas M. Anstey

Glucose-6-Phosphate Dehydrogenase Deficiency and Haemoglobin Drop after Sulphadoxine-Pyrimethamine Use for Intermittent Preventive Treatment of Malaria during Pregnancy in Ghana – A Cohort Study

Ruth Owusu, Kwaku Poku Asante, [ ... ], Seth Owusu-Agyei

Transport Mechanisms and Their Pathology-Induced Regulation Govern Tyrosine Kinase Inhibitor Delivery in Rheumatoid Arthritis

Christian Schmidt-Lauber, Saliha Harrach, [ ... ], Giuliano Ciarimboli

Functional Analysis of Plasmodium vivax Dihydrofolate Reductase-Thymidylate Synthase Genes through Stable Transformation of Plasmodium falciparum

Alyson M. Auliff, Bharath Balu, [ ... ], John H. Adams

Fitness Trade-Offs in the Evolution of Dihydrofolate Reductase and Drug Resistance in Plasmodium falciparum

Marna S. Costanzo, Kyle M. Brown, Daniel L. Hartl

Towards an In Vitro Model of Plasmodium Hypnozoites Suitable for Drug Discovery

Laurent Dembele, Audrey Gego, [ ... ], Dominique Mazier

Effects of Point Mutations in Plasmodium falciparum Dihydrofolate Reductase and Dihydropterate Synthase Genes on Clinical Outcomes and In Vitro Susceptibility to Sulfadoxine and Pyrimethamine

David J. Bacon, Doug Tang, [ ... ], Alan J. Magill

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