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Protein kinases

Mechanistic evaluation of NSC 57774 as a SHP2 inhibitor in gastric cancer: Multi-pathway signaling modulation in vitro

Ghalia Khoder, Rose Ghemrawi, Nour Sammani, Rania Harati, Mohamad Hamad, Jibran Sualeh Muhammad, Walaa Mousa, Mostafa Khair

published 30 Jul 2026

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G-protein coupled receptor, signal and signal-transduction related transcript mapping in nigral volume and pigmented neurons reveals a potential deficit of nigral feedback signals associated with Parkinson’s disease

John M. Haynes

published 24 Jul 2026

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HIV-1 Nef inhibits the JAK/STAT signaling pathway by inducing proteasomal degradation of STAT1

Roger L. Rodrigues, Mara E. da Silva-Januário, Vinicius B. Apolloni, Constanza E. Espada, Taissa R. Jorge, Lucas A. Tavares, Andreia N. de Carvalho, Juliano P. Souza, Eurico Arruda, Iranaia Assunção-Miranda, Daniel S. Mansur, Luis L. P. daSilva

published 10 Jul 2026

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Higher frequency of subclonal anti-EGFR resistance mutations in post-treatment samples from patients with colorectal cancer liver metastases following anti-EGFR-based conversion chemotherapy

Christoph Steup, Antonia Mondorf, Peter Wild, Ursula Pession, Wolf Otto Bechstein, Florian A. Michael, Melanie Winter, Julia Bein, Stefan Zeuzem, Jörg Trojan, Christine Koch

published 06 Jul 2026

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Inhibition of purine nucleoside and nucleobase transporters by tyrosine kinase inhibitors

Nayiar Shahid, Chan H. Kim, Kerrylei B. Jabilona, Khanh H. Nguyen, Nicholas M. Ruel, James R. Hammond

published 15 May 2026

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Phosphorylation landscape of dengue virus proteins and their implications in protein-protein interactions

Prakhar Agrawal, Rahul Yadav, Arumugam Madhumalar, Ganesan Senthil Kumar

published 12 May 2026

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Characterization of the TREM-1 signaling landscape in human neutrophils

Frederic Ries, Matthias Klein, Nora Rogmann, Sophie Többen, Federico Marini, Florian Heidel, Markus P. Radsak

published 05 Mar 2026

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Genome-wide association study revealed genomic regions associated with tuber quality traits in water yam (Dioscorea alata L.)

Fatoumata Ouattara, Paterne A. Agre, Idris I. Adejumobi, Bunmi Olasanmi, Adekemi Stanley, Fatogoma Sorho, Konan E. B. Dibi, Malachy O. Akoroda, Ranjana Bhattacharjee

published 04 Feb 2026

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Identification of cCMP- and cUMP-binding proteins using cCMP and cUMP coupled to agarose and biotin matrices

Sabine Wolter, Martin Neumann, Theresa Koenig, Tina Hagedorn, Frank Schwede, Andreas Pich, Roland Seifert

published 14 Oct 2025

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Evaluating the pentapharmacological potency of otamixaban against lung cancer CDK2, transferase, oxidoreductase and signalling proteins

Hanadi M. Baeissa, Tahani Bakhsh, Afnan Mohammed Shakoori, Ghadir Sindi, Randa Mohammed Zaki, Mohammad Azhar Kamal, Hadeel A. Alsufyani, Alaa Hamed Habib, Arwa Ishaq A. Khayyat, Misbahuddin Rafeeq, Deeba Shamim Jairajpuri

published 09 Oct 2025

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Integrated analysis of ARHGAP6 potential function and prognostic value in acute myeloid leukemia

Debin Yang, Yuanzhe Li, Ping Ma, Fankai Xiao

published 07 Oct 2025

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Anti-cancer compound screening identifies Aurora Kinase A inhibition as a means to favor CRISPR/Cas9 gene correction over knock-out

Danny Wilbie, Selma Eising, Vicky Amo-Addae, Johanna Walther, Esmeralda Bosman, Zhiyong Lei, Olivier G de Jong, Jan J Molenaar, Enrico Mastrobattista

published 26 Sep 2025

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Next-Generation Sequencing (NGS) in non-small cell lung carcinoma: A real-world experience in the public health system of Galicia (Northwest Spain)

Ihab Abdulkader-Nallib, José Manuel Cameselle-Teijeiro, Iván Lesende-Rodríguez, Raquel Pérez-Becerra, José Ramón Antúnez-López, Jorge García-González, Luis León-Mateos, María Sánchez-Ares

published 01 Jul 2025

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