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Protein interaction networks

Anti-hepatocellular carcinoma activity of Jacaranda mimosifolia through experimental validation and network pharmacology

Ayesha Bibi, Muhammad Hamza Afandi, Azra Mehmood, Usman Ali Ashfaq, Muhammad Shareef Masoud, Mohsin Ahmad Khan, Rashid Bhatti

published 03 Apr 2026

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Proteome-based investigation of O-GlcNAcylation in a C. elegans model of ageing and Alzheimer’s disease: Functional support for earlier hypothesis-generating findings

Fernando Garcia Olivera

published 30 Mar 2026

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Integrated network pharmacology and comprehensive bioinformatics analysis to identify the mechanisms and molecular targets of ketamine in ischemic stroke–depression comorbidity

Yunfei Shu, Yinhao Guo, Suihan Xu, Hongxia He, Biao Zeng, Zhenyu Yang, Wei Gao, Jun Li

published 18 Mar 2026

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Identification of novel plasma proteomic biomarkers of Dupuytren disease

Blake Hummer, Paola Sebastiani, Anastasia Leshchyk, Anastasia Gurinovich, Cecilie Bager, Morten Karsdal, Signe Nielsen, Charles Eaton

published 18 Mar 2026

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pH-dependent structural dynamics of neuropeptide Y in aqueous solution

Hoa Thi Nguyen, Marc Spehr, Ana-Nicoleta Bondar, Paolo Carloni

published 12 Mar 2026

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Evaluation of the mechanism underlying melatonin action in cholestatic liver disease treatment via network pharmacology, molecular docking, and in vivo experiments

Tao Li, Jiang ZhenYu, Wang Jing

published 27 Feb 2026

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Comprehensive in silico analysis of genetic landscape and pathways involved in Stickler syndrome

Ravinder Sharma, Kiran Yadav, Vikas Gupta, Anchal Arora, Vikas Yadav

published 20 Feb 2026

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System biology and network-based approach to identify the therapeutic signatures and potential inhibitors against polycystic lipomembranous osteodysplasia with Sclerosing Leukoencephalopathy

Bayan T. Bokhari, Alaa M. Saleh, Hashim M. Aljohani, Wejdan Hussain Owaydhah, Mohammad Ahmad Alobaidy, Naief Dahran, Hind M. Naffadi, Alaa Abdulaziz Eisa

published 20 Feb 2026

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Multi-omics analysis identifies PPARα as a key inhibitor of hepatocyte ferroptosis in sepsis-associated liver injury

Shi-Ling He, Jian-Chuan Lin, Gao-Fang Wu, He-fan He

published 19 Feb 2026

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Elucidating key targets and mechanisms of diethyl phthalate-induced colorectal cancer through network toxicology and molecular docking

Zijing Wang, Liyuan Ma, Zhanyuan Sun, Hengyi Lv, Ruxue Ma, Mengqi Ding, Hai Li, Tao Jiang

published 17 Feb 2026

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In-silico target prediction and pathway analysis of propranolol as a potential therapeutic agent for hepatocellular carcinoma

Ishaq Ahmad, Shakeel Ahmad Khan, Muhammad Abu Bakar, Adnan Shakoor, Abdul Wasy Zia

published 13 Feb 2026

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MAGIN-GO: Protein function prediction based on dual graph neural networks and gene ontology structure

Runxin Li, Wentao Xie, Zhenhong Shang, Xiaowu Li, Guofeng Shu, Lianyin Jia, Wei Peng

published 09 Feb 2026

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Evaluating global measures of network centralization: Axiomatic and numerical assessments

Majid Saberi, Samin Aref

published 05 Feb 2026

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