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Proteasomes

Psmd13, a proteasome regulatory subunit identified in miR-29a regulation during neuronal differentiation

Diji Kuriakose, Grant Morahan, Zhi-cheng Xiao

published 24 Feb 2026

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Auranofin, identified by FDA-approved drug library screening, inhibits HBs antigen secretion via lysosomal damage

Akiyoshi Shimoda, Kazuhiro Murai, Hayato Hikita, Satoshi Minami, Takayuki Miyake, Shinji Kuriki, Emi Sometani, Jihyun Sung, Satoshi Shigeno, Yuichiro Higuchi, Kazuki Maesaka, Kumiko Shirai, Yuki Tahata, Yoshinobu Saito, Takahiro Kodama, Takeshi Takahashi, Hiroshi Suemizu, Tetsuo Takehara

published 16 Jan 2026

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Multifaceted investigations of PSMB8 provides insights into prognostic prediction and immunological target in thyroid carcinoma

Yulou Luo, Yinghui Ye, Yilina Saibaidoula, Yuting Zhang, Yan Chen

published 07 May 2025

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Biochemical analysis to study wild-type and polyglutamine-expanded ATXN3 species

Grégoire Quinet, María Cristina Paz-Cabrera, Raimundo Freire

published 23 Dec 2024

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Therapeutic potential of archaeal unfoldase PAN^et and the gateless T20S proteasome in P23H rhodopsin retinitis pigmentosa mice

Celine Brooks, Douglas Kolson, Emily Sechrest, Janelle Chuah, Jane Schupp, Neil Billington, Wen-Tao Deng, David Smith, Maxim Sokolov

published 03 Oct 2024

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Vaginal Tritrichomonas foetus infection in mice as an in vivo model for drug development against Trichomonas vaginalis

Noelle M. Nieskens, Yukiko Miyamoto, Brianna M. Hurysz, Anthony J. O’Donoghue, Lars Eckmann

published 01 Oct 2024

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Small extracellular vesicles from the human endothelial cell line EA.hy 926 exert a self-cell activation and modulate DENV-2 genome replication and infection in naïve endothelial cells

María-Angélica Calderón-Peláez, L. Johana Madroñero, Jaime E. Castellanos, Myriam L. Velandia-Romero

published 26 Sep 2024

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Enhancing the immunogenicity of Wilms tumor 1 epitope in mesothelioma cells with immunoproteasome inhibitors

Masaki Ito, Shigeo Koido, Takeo Iwamoto, Soyoko Morimoto, Fumihiro Fujiki, Haruo Sugiyama, Saki Matsumoto, Clara Effenberger, Kazuma Kiyotani, Kiyotaka Shiba

published 08 Aug 2024

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Preclinical studies of RA475, a guanidine-substituted spirocyclic candidate RPN13/ADRM1 inhibitor for treatment of ovarian cancer

Ravi K. Anchoori, Ssu-Hsueh Tseng, Hua-Ling Tsai, Vikrant Palande, Michelle A. Rudek, Richard B. S. Roden

published 11 Jul 2024

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Proinsulin degradation and presentation of a proinsulin B-chain autoantigen involves ER-associated protein degradation (ERAD)-enzyme UBE2G2

Tom Cremer, Hanneke Hoelen, Michael L. van de Weijer, George M. Janssen, Ana I. Costa, Peter A. van Veelen, Robert Jan Lebbink, Emmanuel J. H. J. Wiertz

published 24 May 2024

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Autophagy and oxidative stress modulation mediate Bortezomib resistance in prostate cancer

Kalliopi Zafeiropoulou, Georgios Kalampounias, Spyridon Alexis, Daniil Anastasopoulos, Argiris Symeonidis, Panagiotis Katsoris

published 27 Feb 2024

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Clarithromycin overcomes stromal cell-mediated drug resistance against proteasome inhibitors in myeloma cells via autophagy flux blockage leading to high NOXA expression

Shota Moriya, Hiromi Kazama, Hirotsugu Hino, Naoharu Takano, Masaki Hiramoto, Shin Aizawa, Keisuke Miyazawa

published 01 Dec 2023

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Nrf1 is not a direct target gene of SREBP1, albeit both are integrated into the rapamycin-responsive regulatory network in human hepatoma cells

Keli Liu, Shaofan Hu, Lu Qiu, Meng Wang, Zhengwen Zhang, Guiyin Sun, Yiguo Zhang

published 27 Nov 2023

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