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Proteasomes

Auranofin, identified by FDA-approved drug library screening, inhibits HBs antigen secretion via lysosomal damage

Akiyoshi Shimoda, Kazuhiro Murai, [ ... ], Tetsuo Takehara

Multifaceted investigations of PSMB8 provides insights into prognostic prediction and immunological target in thyroid carcinoma

Yulou Luo, Yinghui Ye, [ ... ], Yan Chen

Biochemical analysis to study wild-type and polyglutamine-expanded ATXN3 species

Grégoire Quinet, María Cristina Paz-Cabrera, Raimundo Freire

Therapeutic potential of archaeal unfoldase PAN^et and the gateless T20S proteasome in P23H rhodopsin retinitis pigmentosa mice

Celine Brooks, Douglas Kolson, [ ... ], Maxim Sokolov

Vaginal Tritrichomonas foetus infection in mice as an in vivo model for drug development against Trichomonas vaginalis

Noelle M. Nieskens, Yukiko Miyamoto, [ ... ], Lars Eckmann

Small extracellular vesicles from the human endothelial cell line EA.hy 926 exert a self-cell activation and modulate DENV-2 genome replication and infection in naïve endothelial cells

María-Angélica Calderón-Peláez, L. Johana Madroñero, Jaime E. Castellanos, Myriam L. Velandia-Romero

Enhancing the immunogenicity of Wilms tumor 1 epitope in mesothelioma cells with immunoproteasome inhibitors

Masaki Ito, Shigeo Koido, [ ... ], Kiyotaka Shiba

Preclinical studies of RA475, a guanidine-substituted spirocyclic candidate RPN13/ADRM1 inhibitor for treatment of ovarian cancer

Ravi K. Anchoori, Ssu-Hsueh Tseng, [ ... ], Richard B. S. Roden

Proinsulin degradation and presentation of a proinsulin B-chain autoantigen involves ER-associated protein degradation (ERAD)-enzyme UBE2G2

Tom Cremer, Hanneke Hoelen, [ ... ], Emmanuel J. H. J. Wiertz

Autophagy and oxidative stress modulation mediate Bortezomib resistance in prostate cancer

Kalliopi Zafeiropoulou, Georgios Kalampounias, [ ... ], Panagiotis Katsoris

Clarithromycin overcomes stromal cell-mediated drug resistance against proteasome inhibitors in myeloma cells via autophagy flux blockage leading to high NOXA expression

Shota Moriya, Hiromi Kazama, [ ... ], Keisuke Miyazawa

Nrf1 is not a direct target gene of SREBP1, albeit both are integrated into the rapamycin-responsive regulatory network in human hepatoma cells

Keli Liu, Shaofan Hu, [ ... ], Yiguo Zhang

The ubiquitin-like modifier FAT10 covalently modifies HUWE1 and strengthens the interaction of AMBRA1 and HUWE1

Stefanie Mueller, Johanna Bialas, [ ... ], Annette Aichem

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