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Pro-drugs

Investigation of hydrolysis of olmesartan medoxomil in different pH buffers by simultaneously measuring olmesartan medoxomil and olmesartan

Lauren Landry, Xiaowei Dong

published 02 May 2025

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Pharmacokinetics of isavuconazonium sulfate and its active metabolite isavuconazole in healthy dogs

Erin McQuinn, Jonathan P. Mochel, David Borts, Andrew S. Hanzlicek, Karin Allenspach, Jean-Sébastien Palerme

published 16 Jul 2024

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Physicochemical investigation of a novel curcumin diethyl γ-aminobutyrate, a carbamate ester prodrug of curcumin with enhanced anti-neuroinflammatory activity

Ponsiree Jithavech, Piyapan Suwattananuruk, Hasriadi, Chawanphat Muangnoi, Worathat Thitikornpong, Pasarapa Towiwat, Opa Vajragupta, Pornchai Rojsitthisak

published 18 Mar 2022

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Pharmacological and pharmacokinetic profile of the novel ocular hypotensive prodrug CKLP1 in Dutch-belted pigmented rabbits

Uttio Roy Chowdhury, Rachel A. Kudgus, Tommy A. Rinkoski, Bradley H. Holman, Cindy K. Bahler, Cheryl R. Hann, Joel M. Reid, Peter I. Dosa, Michael P. Fautsch

published 16 Apr 2020

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Cell-permeable succinate prodrugs rescue mitochondrial respiration in cellular models of acute acetaminophen overdose

Sarah Piel, Imen Chamkha, Adam Kozak Dehlin, Johannes K. Ehinger, Fredrik Sjövall, Eskil Elmér, Magnus J. Hansson

published 06 Apr 2020

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Luciferase-based reporting of suicide gene activity in murine mesenchymal stem cells

Dario Gerace, Rosetta Martiniello-Wilks, Rosaline Habib, Ann Margaret Simpson

published 18 Jul 2019

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Design of stable magnetic hybrid nanoparticles of Si-entrapped HRP

Sonali Correa, Sara Puertas, Lucía Gutiérrez, Laura Asín, Jesús Martínez de la Fuente, Valeria Grazú, Lorena Betancor

published 01 Apr 2019

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Predicting inadequate postoperative pain management in depressed patients: A machine learning approach

Arjun Parthipan, Imon Banerjee, Keith Humphreys, Steven M. Asch, Catherine Curtin, Ian Carroll, Tina Hernandez-Boussard

published 06 Feb 2019

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A genetically engineered microRNA-34a prodrug demonstrates anti-tumor activity in a canine model of osteosarcoma

Fernando Alegre, Amanda R. Ormonde, Kellie M. Snider, Kevin Woolard, Ai-Ming Yu, Luke A. Wittenburg

published 31 Dec 2018

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Prodrugs for colon-restricted delivery: Design, synthesis, and in vivo evaluation of colony stimulating factor 1 receptor (CSF1R) inhibitors

Dawn M. George, Raymond J. Huntley, Kevin Cusack, David B. Duignan, Michael Hoemann, Jacqueline Loud, Regina Mario, Terry Melim, Kelly Mullen, Gagandeep Somal, Lu Wang, Jeremy J. Edmunds

published 07 Sep 2018

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Novel multipurpose pod-intravaginal ring for the prevention of HIV, HSV, and unintended pregnancy: Pharmacokinetic evaluation in a macaque model

James M. Smith, John A. Moss, Priya Srinivasan, Irina Butkyavichene, Manjula Gunawardana, Rob Fanter, Christine S. Miller, Debbie Sanchez, Flora Yang, Shanon Ellis, Jining Zhang, Mark A. Marzinke, Craig W. Hendrix, Amita Kapoor, Marc M. Baum

published 05 Oct 2017

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Anticancer actions of lysosomally targeted inhibitor, LCL521, of acid ceramidase

Aiping Bai, Cungui Mao, Russell W. Jenkins, Zdzislaw M. Szulc, Alicja Bielawska, Yusuf A. Hannun

published 14 Jun 2017

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Rapid Recovery of Visual Function Associated with Blue Cone Ablation in Zebrafish

Gordon F. Hagerman, Nicole C. L. Noel, Sylvia Y. Cao, Michèle G. DuVal, A. Phillip Oel, W. Ted Allison

published 28 Nov 2016

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