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Pharmacokinetics

Erlotinib in a once-daily high-dose oral regimen could mitigate Chikungunya virus titer in mice

Chidinma Nelson Orji, Naphat Loeanurit, Akeanan Sroithongmoon, Noppadol Wacharachaisurapol, Yaowatree Jumroen, Wanna Eiamart, Supeecha Wittayalertpanya, Weerachai Chaijamorn, Tatta Sriboonruang, Jirapat Vamananda, Tanatorn Khotavivattana, Siwaporn Boonyasuppayakorn

published 02 Nov 2026

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Physical risk factors associated with central serous chorioretinopathy: A protocol for a systematic review and meta-analysis

Olivia Cundy, William Wilson, Catey Bunce, Timothy L. Jackson

published 29 Oct 2026

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Clinical pharmacokinetic-pharmacodynamic relationships between drug exposure and the QT/QTc interval: Protocol for a systematic review and quantitative synthesis

Hoornaz Molana, Hadi Esmaily, Ghader Mohammadnezhad

published 28 Oct 2026

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Dexmedetomidine effects on metabolic rate over 5 days in humans

Clifton W. Callaway, Alexandra J. Weissman, Katharyn L. Flickinger, Victor Wu, Jenna Monteleone, Ryann DeMaio, Mara Hierro, Daniel Neofes, Omarf Ortega-Reyes, Tao Sheng, Marianna Salinas, Paul Lerro, Francis X. Guyette, Benjamin D. H. Gordon, Marie Mortreux, Kathleen Melanson, Daniel J. Buysee, Philip E. Empey

published 27 Oct 2026

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Buccal and sublingual lyophilised naloxone for opioid overdose reversal: A Phase 1 open-label, random-sequence crossover pharmacokinetic study protocol in healthy volunteers (NalBuc)

Mariana Gonzalez Utrilla, Alexander Baker, Edward Chesney, Kim Lee, Richard Emsley, John Strang

published 27 Oct 2026

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Pharmacokinetic diversity of baloxavir marboxil across rare avian species

Yo Shimazu, Ryo Daniel Obara, Mariko Miki, Hiromi Osaki, Yuto Yoshimoto, Marina Hayashi, Kosuke Toyoda, Miki Ozaki, Ikumi Hanada, Rei Matsumoto, Kaori Ota, Ayumi Yamaguchi, Kosuke Toda, Junko Ishii, Tsuneo Kizaki, Yuzo Hirano, Yuma Sugimoto, Yukiko Watanabe, Keisuke Saito, Masato Kaku, Izumi Ide, Akihiro Sado, Hidefumi Sakai, Kyohei Nishimura, Mayumi Endo, Takahiro Hiono, Norikazu Isoda, Takao Shishido, Yoshinori Ikenaka, Yoshihiro Sakoda

published 23 Oct 2026

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A cohort-based population model for the Poultry Red Mite Dermanyssus gallinae (Acari: Dermanyssidae): Application to explore potential pathways for control strategies using Fluralaner as a case study

Maroua Bettaieb, Ahmed Louhichi, Mohamed Aziz Darghouth, Slimane Ben Miled

published 21 Oct 2026

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Development and clinical validation of HPLC method for precise quantification of paclitaxel in plasma from breast cancer patients

Najia Rahim, Sadia Shakeel, Maryum Nouman, Sadia Asim, Javeria Chaudhry, Zulqarnain Hassan

published 08 Oct 2026

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Ticagrelor and gut microbiota: Absence of pharmacokinetic interaction in vitro and in vivo studies

Pan Qu, Yongchao Gao, Xiaojie Li, Li Yang, Jie Tang, Manyun Chen, Yicheng Wang, Yilei Peng, Junyi Jiang, Weihua Huang, Wei Zhang, Yali Liu, Yali Ou

published 01 Oct 2026

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Levels of IgG subclasses 1–4 in BT595, a 10% IVIG: A sub-analysis of a clinical trial

Fabian Bohländer, Silke Aigner, Joachim Schütze, Jörg Schüttrumpf, Christiane Staiger

published 25 Sep 2026

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Orchestration of kaempferol nuclear translocation by phase ii metabolic enzymes and efflux transporters suppresses colorectal cancer

Chishun Zhou, Qing Ning, Xin Jin, Yu Li, Yuefang Lin, Jiarun Lin, Jing Zheng, Yukai Huang, Wei Wang, Zhongqiu Liu, Linlin Lu

published 15 Sep 2026

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Ketogenic diet–induced changes in hepatic drug metabolism with potential implications for ozanimod pharmacokinetics in mice

Veronika Frybortova, Stefan Satka, Lenka Jourova, Pavel Anzenbacher, Iveta Zapletalova, Michal Kraus, Klara Kostovcikova, Miloslav Kverka, Eva Anzenbacherova

published 08 Sep 2026

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Computational identification and evaluation of Adenium obesum phytochemicals as potential EGFR inhibitors for targeted therapy against non-small-cell lung cancer

Md. Naziur Rahman, Abu Yousuf Hossin, Shahriar Mannan Imon Talukder, Mt. Sumaiya Siddika, Md. Harun-Ur-Rashid, Shahanaz Parveen, Md. Ridwanul Islam, Md. Yeamin Hossain, Mahfuj Ahmed, Brototi Chakraborty Dyuti, Zarin Tabassum, Ajoy Kumer

published 31 Aug 2026

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