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Pegylation

Efficacy of PEGylated ciliary neurotrophic factor superagonist variant in diet-induced obesity mice

Maria Rosaria Battista, Antonella Grigoletto, Tommaso Tedeschini, Antonella Cellucci, Fabrizio Colaceci, Ralph Laufer, Gianfranco Pasut, Annalise Di Marco

published 22 Mar 2022

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Site-specific PEGylation of micro-plasmin for improved thrombolytic therapy through engineering enhanced resistance against serpin mediated inhibition

Navneet Kaur, Prakash Kumar Sinha, Girish Sahni

published 29 May 2019

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Structural similarity, characterization of Poly Ethylene Glycol linkage and identification of product related variants in biosimilar pegfilgrastim

Rakesh Shekhawat, Chintan Kumar Shah, Akash Patel, Sankaranarayanan Srinivasan, Poonam Kapoor, Suvaskumar Patel, Sharwan Kumar, Sandeep Sonar, Namrata More, Manasvi Joshi, Jatin Patel, Milan Vachhani, Bhargav Prasad Kodaganti, Upasana Choavatiya, Arabhi Pushpaja, Shubhangi Argade, Nidhi Nuwal, Manish Kumar, Sridevi Khambhampaty

published 13 Mar 2019

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Novel site-specific PEGylated L-asparaginase

Giovanna Pastore Meneguetti, João Henrique Picado Madalena Santos, Karin Mariana Torres Obreque, Christiano Marcello Vaz Barbosa, Gisele Monteiro, Sandra Helena Poliselli Farsky, Adriano Marim de Oliveira, Claudia Blanes Angeli, Giuseppe Palmisano, Sónia Patrícia Marques Ventura, Adalberto Pessoa-Junior, Carlota de Oliveira Rangel-Yagui

published 12 Feb 2019

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Thiol-maleimide poly(ethylene glycol) crosslinking of L-asparaginase subunits at recombinant cysteine residues introduced by mutagenesis

Josell Ramirez-Paz, Manoj Saxena, Louis J. Delinois, Freisa M. Joaquín-Ovalle, Shiru Lin, Zhongfang Chen, Virginia A. Rojas-Nieves, Kai Griebenow

published 27 Jul 2018

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Discovery of a novel potent peptide agonist to adiponectin receptor 1

Sunghwan Kim, Younho Lee, Jun Woo Kim, Young-Jin Son, Min Jung Ma, Jee-Hyun Um, Nam Doo Kim, Sang Hyun Min, Dong Il Kim, Brian B. Kim

published 18 Jun 2018

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PEGylation of zinc nanoparticles amplifies their ability to enhance olfactory responses to odorant

Melissa Singletary, Samantha Hagerty, Shin Muramoto, Yasmine Daniels, William A. MacCrehan, Gheorghe Stan, June W. Lau, Oleg Pustovyy, Ludmila Globa, Edward E. Morrison, Iryna Sorokulova, Vitaly Vodyanoy

published 20 Dec 2017

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Modeling the receptor pharmacology, pharmacokinetics, and pharmacodynamics of NKTR-214, a kinetically-controlled interleukin-2 (IL2) receptor agonist for cancer immunotherapy

Deborah Charych, Samira Khalili, Vidula Dixit, Peter Kirk, Thomas Chang, John Langowski, Werner Rubas, Stephen K. Doberstein, Michael Eldon, Ute Hoch, Jonathan Zalevsky

published 05 Jul 2017

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Formulation and PEGylation optimization of the therapeutic PEGylated phenylalanine ammonia lyase for the treatment of phenylketonuria

Sean M. Bell, Dan J. Wendt, Yanhong Zhang, Timothy W. Taylor, Shinong Long, Laurie Tsuruda, Bin Zhao, Phillip Laipis, Paul A. Fitzpatrick

published 10 Mar 2017

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Polyethylene Glycol Camouflaged Earthworm Hemoglobin

Vivek P. Jani, Alborz Jelvani, Selamawit Moges, Parimala Nacharaju, Camille Roche, David Dantsker, Andre Palmer, Joel M. Friedman, Pedro Cabrales

published 18 Jan 2017

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A Therapeutic Uricase with Reduced Immunogenicity Risk and Improved Development Properties

Andrew C. Nyborg, Chris Ward, Anna Zacco, Benoy Chacko, Luba Grinberg, James C. Geoghegan, Ryan Bean, Michaela Wendeler, Frank Bartnik, Ellen O’Connor, Flaviu Gruia, Vidyashankara Iyer, Hui Feng, Varnika Roy, Mark Berge, Jeffrey N. Miner, David M. Wilson, Dongmei Zhou, Simone Nicholson, Clynn Wilker, Chi Y. Wu, Susan Wilson, Lutz Jermutus, Herren Wu, David A. Owen, Jane Osbourn, Steven Coats, Manuel Baca

published 21 Dec 2016

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PEGylation of Truncated Streptokinase Leads to Formulation of a Useful Drug with Ameliorated Attributes

Pooja Sawhney, Keya Katare, Girish Sahni

published 18 May 2016

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Discovery and Characterization of a Potent Interleukin-6 Binding Peptide with Neutralizing Activity In Vivo

Sheila Ranganath, Ashok Bhandari, Nicole Avitahl-Curtis, Jaimee McMahon, Derek Wachtel, Jenny Zhang, Christopher Leitheiser, Sylvie G. Bernier, Guang Liu, Tran T. Tran, Herodion Celino, Jenny Tobin, Joon Jung, Hong Zhao, Katie E. Glen, Chris Graul, Aliesha Griffin, Wayne C. Schairer, Carolyn Higgins, Tammi L. Reza, Eva Mowe, Sam Rivers, Sonya Scott, Alex Monreal, Courtney Shea, Greg Bourne, Casey Coons, Adaline Smith, Kim Tang, Ramya A. Mandyam, Jaime Masferrer, David Liu, Dinesh V. Patel, Angelika Fretzen, Craig A. Murphy, G. Todd Milne, Mark L. Smythe, Kenneth E. Carlson

published 10 Nov 2015

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