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Patch clamp techniques

A novel methodology to characterize beat-to-beat alternations in whole-cell calcium currents

Xavier Marimon, Miguel Cerrolaza, Carmen Tarifa, Leif Hove-Madsen

published 28 Jan 2026

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Select amino acids recover cytokine-altered ENaC function in human bronchial epithelial cells

Anusree Sasidharan, Astrid Grosche, Xiaodong Xu, T. Bernard Kinane, Damiano Angoli, Sadasivan Vidyasagar

published 25 Jul 2024

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Side-by-side comparison of published small molecule inhibitors against thapsigargin-induced store-operated Ca²⁺ entry in HEK293 cells

Katherine Norman, Karen E. Hemmings, Heba Shawer, Hollie L. Appleby, Alan J. Burnett, Nurasyikin Hamzah, Rajendra Gosain, Emily M. Woodhouse, David J. Beech, Richard Foster, Marc A. Bailey

published 23 Jan 2024

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Experimental factors that impact Ca_V1.2 channel pharmacology—Effects of recording temperature, charge carrier, and quantification of drug effects on the step and ramp currents elicited by the “step-step-ramp” voltage protocol

Ming Ren, Aaron L. Randolph, Claudia Alvarez-Baron, Donglin Guo, Phu N. Tran, Nicolas Thiebaud, Jiansong Sheng, Jun Zhao, Wendy W. Wu

published 23 Nov 2022

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Transfection methods for high-throughput cellular assays of voltage-gated calcium and sodium channels involved in pain

Md. Mahadhi Hasan, Lotten Ragnarsson, Fernanda C. Cardoso, Richard J. Lewis

published 05 Mar 2021

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Sleep-related hypermotor epilepsy associated mutations uncover important kinetic roles of α4β2- nicotinic acetylcholine receptor intracellular structures

Maegan M. Weltzin, Andrew A. George, Ronald J. Lukas, Paul Whiteaker

published 03 Mar 2021

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Toward in vivo-relevant hERG safety assessment and mitigation strategies based on relationships between non-equilibrium blocker binding, three-dimensional channel-blocker interactions, dynamic occupancy, dynamic exposure, and cellular arrhythmia

Hongbin Wan, Gianluca Selvaggio, Robert A. Pearlstein

published 04 Nov 2020

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Comparison of biophysical properties of α1β2 and α3β2 GABA_A receptors in whole-cell patch-clamp electrophysiological recordings

Emma Rie Olander, Dieter Janzen, Carmen Villmann, Anders A. Jensen

published 01 Jun 2020

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Distinctive single-channel properties of α4β2-nicotinic acetylcholine receptor isoforms

Maegan M. Weltzin, Andrew A. George, Ronald J. Lukas, Paul Whiteaker

published 07 Mar 2019

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In vivo, in vitro and in silico correlations of four de novo SCN1A missense mutations

Andreea Nissenkorn, Yael Almog, Inbar Adler, Mary Safrin, Marina Brusel, Milit Marom, Shayel Bercovich, Daniel Yakubovich, Michal Tzadok, Bruria Ben-Zeev, Moran Rubinstein

published 08 Feb 2019

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TRPM7 residue S1269 mediates cAMP dependence of Ca²⁺ influx

Jorrit Broertjes, Jeffrey Klarenbeek, Yasmin Habani, Michiel Langeslag, Kees Jalink

published 07 Jan 2019

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Functional analyses of heteromeric human PIEZO1 Channels

Radhakrishnan Gnanasambandam, Chilman Bae, Lynn Ziegler, Frederick Sachs, Philip A. Gottlieb

published 21 Nov 2018

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Lipid bilayer-atomic force microscopy combined platform records simultaneous electrical and topological changes of the TRP channel polycystin-2 (TRPP2)

Sumit Lal, Noelia Scarinci, Paula L. Perez, María del Rocío Cantero, Horacio F. Cantiello

published 22 Aug 2018

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