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Partial agonists

Descriptive molecular pharmacology of the δ opioid receptor (DOR): A computational study with structural approach

Guillermo Goode-Romero, Laura Dominguez

published 11 Jul 2024

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Reflected generalized concentration addition and Bayesian hierarchical models to improve chemical mixture prediction

Daniel Zilber, Kyle Messier

published 28 Mar 2024

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Development and application of high-throughput screens for the discovery of compounds that disrupt ErbB4 signaling: Candidate cancer therapeutics

Richard L. Cullum, Lauren M. Lucas, Jared I. Senfeld, John T. Piazza, Logan T. Neel, Kanupriya Whig, Ling Zhai, Mackenzie H. Harris, Cristina C. Rael, Darby C. Taylor, Laura J. Cook, David P. Kaufmann, Christopher P. Mill, Megan A. Jacobi, Forrest T. Smith, Mark Suto, Robert Bostwick, Ram B. Gupta, Allan E. David, David J. Riese, II

published 30 Dec 2020

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Dual inhibitory action of trazodone on dorsal raphe serotonergic neurons through 5-HT_1A receptor partial agonism and α₁-adrenoceptor antagonism

Alberto Montalbano, Boris Mlinar, Francesco Bonfiglio, Lorenzo Polenzani, Maurizio Magnani, Renato Corradetti

published 26 Sep 2019

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Comprehensive molecular pharmacology screening reveals potential new receptor interactions for clinically relevant opioids

Keith M. Olson, David I. Duron, Daniel Womer, Ryan Fell, John M. Streicher

published 06 Jun 2019

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5-HT₂ receptor binding, functional activity and selectivity in N-benzyltryptamines

Miguel Toro-Sazo, José Brea, María I. Loza, Marta Cimadevila, Bruce K. Cassels

published 10 Jan 2019

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NOP receptor pharmacological profile – A dynamic mass redistribution study

Davide Malfacini, Katharina Simon, Claudio Trapella, Remo Guerrini, Nurulain T. Zaveri, Evi Kostenis, Girolamo Calo’

published 30 Aug 2018

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GPR40 partial agonists and AgoPAMs: Differentiating effects on glucose and hormonal secretions in the rodent

Michele J. Pachanski, Melissa E. Kirkland, Daniel T. Kosinski, Joel Mane, Boonlert Cheewatrakoolpong, Jiyan Xue, Daphne Szeto, Gail Forrest, Corin Miller, Michelle Bunzel, Christopher W. Plummer, Harry R. Chobanian, Michael W. Miller, Sarah Souza, Brande S. Thomas-Fowlkes, Aimie M. Ogawa, Adam B. Weinglass, Jerry Di Salvo, Xiaoyan Li, Yue Feng, Daniel A. Tatosian, Andrew D. Howard, Steven L. Colletti, Maria E. Trujillo

published 20 Oct 2017

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Discovery of novel brain permeable and G protein-biased beta-1 adrenergic receptor partial agonists for the treatment of neurocognitive disorders

Bitna Yi, Alam Jahangir, Andrew K. Evans, Denise Briggs, Kristine Ravina, Jacqueline Ernest, Amir B. Farimani, Wenchao Sun, Jayakumar Rajadas, Michael Green, Evan N. Feinberg, Vijay S. Pande, Mehrdad Shamloo

published 26 Jul 2017

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GPR40 partial agonist MK-2305 lower fasting glucose in the Goto Kakizaki rat via suppression of endogenous glucose production

Corin Miller, Michele J. Pachanski, Melissa E. Kirkland, Daniel T. Kosinski, Joel Mane, Michelle Bunzel, Jin Cao, Sarah Souza, Brande Thomas-Fowlkes, Jerry Di Salvo, Adam B. Weinglass, Xiaoyan Li, Robert W. Myers, Kevin Knagge, Paul E. Carrington, William K. Hagmann, Maria E. Trujillo

published 23 May 2017

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Synthesis and biological evaluation of dihydropyrano-[2,3-c]pyrazoles as a new class of PPARγ partial agonists

Katrine Qvortrup, Jakob F. Jensen, Mikael S. Sørensen, Irene Kouskoumvekaki, Rasmus K. Petersen, Olivier Taboureau, Karsten Kristiansen, Thomas E. Nielsen

published 28 Feb 2017

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Ligand Binding at the α4-α4 Agonist-Binding Site of the α4β2 nAChR Triggers Receptor Activation through a Pre-Activated Conformational State

Dinesh C. Indurthi, Trevor M. Lewis, Philip K. Ahring, Thomas Balle, Mary Chebib, Nathan L. Absalom

published 23 Aug 2016

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Investigating the Role of Loop C Hydrophilic Residue ‘T244’ in the Binding Site of ρ1 GABA_C Receptors via Site Mutation and Partial Agonism

Moawiah M. Naffaa, Nathan Absalom, V. Raja Solomon, Mary Chebib, David E. Hibbs, Jane R. Hanrahan

published 31 May 2016

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