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Organoids

Podocyte injury damages podocytes in chimeric organoids

Tomohiro Udagawa, Toshikazu Araoka, Kenji Osafune, Taiji Matsusaka

published 31 Aug 2026

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A chemically optimized, GalNAc-conjugated siRNA targeting HSD17B13 demonstrates efficacy in a human 3D organoid model of MASH, showcasing an alternative to animal testing

Qin Meng, Xujia Wang, Yuxuan Zhang, Sudeep Pushpakom, Jun Yang, Hui Feng, Mu Wang

published 14 Aug 2026

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12-HHT is associated with epithelial barrier enhancement and reduced inflammatory responses in colon organoids of normoganglionosis in Hirschsprung’s disease

Kazuto Suda, Kumpei Abe, Yurina Nishimura, Masafumi Tanaka, Yuki Nagasako, Xuxuan Rao, Jianqin Zhang, Siyi Zeng, Kentaro Fujiwara, Shunsuke Yamada, Junya Ishii, Shiho Yoshida, Soichi Shibuya, Go Miyano

published 16 Jul 2026

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Differential analysis of Short chain fatty acids incubation in autistic organoids based on transcriptome sequencing

Zaixin Wu, Xinyi Liu, Xiaobo Han, Miao Li

published 05 Jun 2026

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A comparative study of organoid-derived and cell line-derived intestinal epithelial models

Melis Asal, Nanne J. Paauw, Hetty J. Bontkes, Sandra J. van Vliet, Reina E. Mebius, Susan Gibbs

published 16 Apr 2026

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Biobanking of gynecologic cancer biospecimens: Development, quality control, and translational applications

Jue Young Kim, Yoo-Kyung Lee, Ha-Yeon Shin, Yoon Joo Kim, Mi Ae Jeon, Wookyeom Yang, Anna Jun, Kyungmin Kim, Hanbyoul Cho, Min-A Kim, Jae-Hoon Kim

published 31 Mar 2026

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Patient-derived organoids predict chemotherapy response of locally advanced gastric cancer

Miao Huang, Jiahui Chu, Wenbin Yu, Liliang Dou, Qiushi Wang, Fan Jiang, Meng Wei, Xiaohan Cui, Wen Zhao, Jianyuan Zhou, Song Li, Lian Liu

published 09 Mar 2026

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Wnt/β-catenin signalling modulates the timing of cell fate decision making in the early mouse embryo

Joaquin Lilao-Garzón, Elena Corujo-Simon, Meritxell Vinyoles, Sabine C. Fischer, José Guillén, Tina Balayo, Silvia Muñoz-Descalzo

published 06 Mar 2026

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Taurocholic acid induces intrahepatic cholangiocyte cell proliferation via activating NRAS and YAP1

Lum Fube, Arul Thason, Elizabeth Taliaferro, Carol Heckman, Surya Amarachintha

published 04 Feb 2026

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DNA methylation-driven gene-based drug response prediction model for liver cancer: The critical role of GLS

Shuang Zheng, Xi Yu, Xiaozhou Wang, Yi Ma, Yujia Han, Jing Zhang, Wei Wu, Chunyu Sun, Lijie He

published 05 Dec 2025

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Establishment and culture of mouse oviductal organoids and isolation and characterization of their secreted extracellular vesicles

Riley E. Thompson-Brandhagen, Mindy A. Meyers, Richard B. McCosh, Fiona K. Hollinshead

published 04 Dec 2025

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Matrix stiffness influences drug resistance to gemcitabine analog and AZD 1775 combination in PDAC organoids

Jonathan Barajas, Zhi Yang, Edward Agyare, Xueyou Zhu, Saun-Joo Yoon, Bo Han

published 04 Dec 2025

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Synergistic enhancement of AAV gene delivery in 2D cells and 3D organoids using polybrene and hydroxychloroquine

Hyeon-Jin Na, Yongbo Shin, Seung-Hyun Kim, Seung Pil Jang, Myung Jin Son, Yong Min Choi, Hyeon Gyeol Jeon, Ok-Seon Kwon, Kyung-Sook Chung

published 14 Nov 2025

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