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Organoids

A chemically optimized, GalNAc-conjugated siRNA targeting HSD17B13 demonstrates efficacy in a human 3D organoid model of MASH, showcasing an alternative to animal testing

Qin Meng, Xujia Wang, [ ... ], Mu Wang

12-HHT is associated with epithelial barrier enhancement and reduced inflammatory responses in colon organoids of normoganglionosis in Hirschsprung’s disease

Kazuto Suda, Kumpei Abe, [ ... ], Go Miyano

Differential analysis of Short chain fatty acids incubation in autistic organoids based on transcriptome sequencing

Zaixin Wu, Xinyi Liu, Xiaobo Han, Miao Li

A comparative study of organoid-derived and cell line-derived intestinal epithelial models

Melis Asal, Nanne J. Paauw, [ ... ], Susan Gibbs

Biobanking of gynecologic cancer biospecimens: Development, quality control, and translational applications

Jue Young Kim, Yoo-Kyung Lee, [ ... ], Jae-Hoon Kim

Patient-derived organoids predict chemotherapy response of locally advanced gastric cancer

Miao Huang, Jiahui Chu, [ ... ], Lian Liu

Wnt/β-catenin signalling modulates the timing of cell fate decision making in the early mouse embryo

Joaquin Lilao-Garzón, Elena Corujo-Simon, [ ... ], Silvia Muñoz-Descalzo

Taurocholic acid induces intrahepatic cholangiocyte cell proliferation via activating NRAS and YAP1

Lum Fube, Arul Thason, [ ... ], Surya Amarachintha

DNA methylation-driven gene-based drug response prediction model for liver cancer: The critical role of GLS

Shuang Zheng, Xi Yu, [ ... ], Lijie He

Establishment and culture of mouse oviductal organoids and isolation and characterization of their secreted extracellular vesicles

Riley E. Thompson-Brandhagen, Mindy A. Meyers, Richard B. McCosh, Fiona K. Hollinshead

Matrix stiffness influences drug resistance to gemcitabine analog and AZD 1775 combination in PDAC organoids

Jonathan Barajas, Zhi Yang, [ ... ], Bo Han

Synergistic enhancement of AAV gene delivery in 2D cells and 3D organoids using polybrene and hydroxychloroquine

Hyeon-Jin Na, Yongbo Shin, [ ... ], Kyung-Sook Chung

STAG2 mutations in the normal colon induce upregulation of oncogenic pathways in neighbouring wildtype cells

Wei Ni Yew, Christopher James Dean, Dedrick Kok Hong Chan

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