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Microsomes

A chemically optimized, GalNAc-conjugated siRNA targeting HSD17B13 demonstrates efficacy in a human 3D organoid model of MASH, showcasing an alternative to animal testing

Qin Meng, Xujia Wang, [ ... ], Mu Wang

Dual effects of indoxyl sulfate on modulation of human hepatic CYP3A activity, with individual differences

Masao Togao, Naoyuki Asakawa, [ ... ], Koji Kawakami

In vitro safety evaluation of dopamine D₃R antagonist, R-VK4-116, as a potential medication for the treatment of opioid use disorder

Rahul M. Nandre, Amy Hauck Newman, Pramod S. Terse

Identification and quantification of the molecular species of bilirubin BDG, BMG and UCB by LC‒MS/MS in hyperbilirubinemic human serum

Stephany M. Castillo-Castañeda, Liliana Rivera-Espinosa, [ ... ], Nahum Méndez-Sánchez

The effects of CYP2B6 inactivators on the metabolism of ciprofol

Ming Lu, Xiaorui Zhang, [ ... ], Zhiqing Zhang

Pharmacokinetic profile of oral and subcutaneous administration of paracetamol in the koala (Phascolarctos cinereus) and prediction of its analgesic efficacy

Merran Govendir, Larry Vogelnest, [ ... ], Benjamin Kimble

Pharmacogenomics of poor drug metabolism in greyhounds: Canine P450 oxidoreductase genetic variation, breed heterogeneity, and functional characterization

Stephanie E. Martinez, Amit V. Pandey, [ ... ], Michael H. Court

Impact of valproic acid on busulfan pharmacokinetics: In vitro assessment of potential drug-drug interaction

Bashayer F. Al-Enezi, Nada Al-Hasawi, Kamal M. Matar

Alkaline ceramidase catalyzes the hydrolysis of ceramides via a catalytic mechanism shared by Zn²⁺-dependent amidases

Jae Kyo Yi, Ruijuan Xu, [ ... ], Cungui Mao

Glycyrrhiza uralensis promote the metabolism of toxic components of Aconitum carmichaeli by CYP3A and alleviate the development of chronic heart failure

Lulu Ni, Ping Miao, [ ... ], Su Tu

Enrichment of microsomes from Chinese hamster ovary cells by subcellular fractionation for its use in proteomic analysis

Saumel Pérez-Rodriguez, María de Jesús Ramírez-Lira, [ ... ], Norma A. Valdez-Cruz

Hydrogenosomal tail-anchored proteins are targeted to both mitochondria and ER upon their expression in yeast cells

Andrè Ferdigg, Kai S. Dimmer, Doron Rapaport, Daniela G. Vitali

In vitro hepatic metabolism of mefloquine using microsomes from cats, dogs and the common brush-tailed possum (Trichosurus vulpecula)

Aaron Michael Izes, Benjamin Kimble, Jacqueline Marie Norris, Merran Govendir

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