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Microsomes

The N-terminus of Sec61p plays key roles in ER protein import and ERAD

Francesco Elia, Lalitha Yadhanapudi, Thomas Tretter, Karin Römisch

Validated LC-MS/MS assay for quantification of the newly approved tyrosine kinase inhibitor, dacomitinib, and application to investigating its metabolic stability

Ali S. Abdelhameed, Adnan A. Kadi, Mohamed W. Attwa, Haitham AlRabiah

Effect of Sec61 interaction with Mpd1 on endoplasmic reticulum-associated degradation

Fabio Pereira, Mandy Rettel, [ ... ], Karin Römisch

Use of a sequential high throughput screening assay to identify novel inhibitors of the eukaryotic SRP-Sec61 targeting/translocation pathway

Wolfgang Klein, Claudia Rutz, [ ... ], Ralf Schülein

Deuterium isotope effects in drug pharmacokinetics II: Substrate-dependence of the reaction mechanism influences outcome for cytochrome P450 cleared drugs

Hao Sun, David W. Piotrowski, [ ... ], Alfin D. N. Vaz

Repurposing antimalarial aminoquinolines and related compounds for treatment of retinal neovascularization

Danielle McAnally, Khandaker Siddiquee, [ ... ], Layton H. Smith

The JAK2/STAT3 inhibitor pacritinib effectively inhibits patient-derived GBM brain tumor initiating cells in vitro and when used in combination with temozolomide increases survival in an orthotopic xenograft model

Katharine Victoria Jensen, Orsolya Cseh, [ ... ], Hema Artee Luchman

Flavin-containing monooxygenase 3 (FMO3) role in busulphan metabolic pathway

Ibrahim El-Serafi, Ylva Terelius, [ ... ], Moustapha Hassan

Effect of erythropoietin administration on proteins participating in iron homeostasis in Tmprss6-mutated mask mice

Jana Frýdlová, Zuzana Rychtarčíková, [ ... ], Jan Krijt

Chemical crosslinking and mass spectrometry to elucidate the topology of integral membrane proteins

Mykhaylo O. Debelyy, Patrice Waridel, [ ... ], Andreas Conzelmann

Feeding-fasting dependent recruitment of membrane microdomain proteins to lipid droplets purified from the liver

Kritika Sadh, Priyanka Rai, Roop Mallik

Discovery of novel brain permeable and G protein-biased beta-1 adrenergic receptor partial agonists for the treatment of neurocognitive disorders

Bitna Yi, Alam Jahangir, [ ... ], Mehrdad Shamloo

Identification of benzazole compounds that induce HIV-1 transcription

Jason D. Graci, Daniel Michaels, [ ... ], Andrew J. Henderson

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